Evidence map›Paper›PMID 38783999›Full record

ArticleiScience2024

Base-pairing of uracil and 2,6-diaminopurine: from cocrystals to photoreactivity.

Tomislav Stolar, Ben K D Pearce, Martin Etter, Khai-Nghi Truong, Tea Ostojić, Andraž Krajnc, Gregor Mali, Barbara Rossi, Krešimir Molčanov, Ivor Lončarić and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Molecules (Basel, Switzerland) · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Tomislav StolarRuđer Bošković Institute, Bijenička c. 54, 10000 Zagreb, Croatia.
Ben K D PearceJohns Hopkins University, 3400 N. Charles Street, Baltimore, MD 21218, USA.
Martin EtterDeutsches Elektronen-Synchrotron (DESY), Notkestraße 85, 22607 Hamburg, Germany.
Khai-Nghi TruongRigaku Europe SE, Hugenottenallee 167, 63263 Neu-Isenburg, Germany.
Tea OstojićRuđer Bošković Institute, Bijenička c. 54, 10000 Zagreb, Croatia.
Andraž KrajncNational Institute of Chemistry, Hajdrihova 19, 1000 Ljubljana, Slovenia.
Gregor MaliNational Institute of Chemistry, Hajdrihova 19, 1000 Ljubljana, Slovenia.
Barbara RossiElettra Sincrotrone Trieste, Strada Statale 14 km 163.5, 34149 Trieste, Italy.
Krešimir MolčanovRuđer Bošković Institute, Bijenička c. 54, 10000 Zagreb, Croatia.
Ivor LončarićRuđer Bošković Institute, Bijenička c. 54, 10000 Zagreb, Croatia.
Ernest MeštrovićFaculty of Chemical Engineering and Technology, University of Zagreb, Trg Marka Marulića 19, 10000 Zagreb, Croatia.
Krunoslav UžarevićRuđer Bošković Institute, Bijenička c. 54, 10000 Zagreb, Croatia.
Luca GrisantiRuđer Bošković Institute, Bijenička c. 54, 10000 Zagreb, Croatia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We show that the non-canonical nucleobase 2,6-diaminopurine (D) spontaneously base pairs with uracil (U) in water and the solid state without the need to be attached to the ribose-phosphate backbone. Depending on the reaction conditions, D and U assemble in thermodynamically stable hydrated and anhydrated D-U base-paired cocrystals. Under UV irradiation, an aqueous solution of D-U base-pair undergoes photochemical degradation, while a pure aqueous solution of U does not. Our simulations suggest that D may trigger the U photodimerization and show that complementary base-pairing modifies the photochemical properties of nucleobases, which might have implications for prebiotic chemistry.

Indexed as

ChemistryTheoretical photochemistry

Identifiers

PMID38783999
PMCPMC11112615

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.