Evidence map›Paper›PMID 38783854›Full record

ArticleOrganic process research & development2024

A Coalescing Filter for Liquid-Liquid Separation and Multistage Extraction in Continuous-Flow Chemistry.

James Daglish, A John Blacker, Gregory de Boer, Stephen J Russell, Muhammad Tausif, David R J Hose, Anna R Parsons, Alex Crampton, Nikil Kapur

Abstract read
In one paragraph

Article in Organic process research & development, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. From Molecules to Modules: Advanced Characterization of Membrane Systems.Advanced materials (Deerfield Beach, Fla.) · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

James DaglishSchool of Mechanical Engineering, University of Leeds, Leeds LS2 9JT, United Kingdom.ORCID https://orcid.org/0000-0001-6148-4035
A John BlackerSchool of Chemistry, University of Leeds, Leeds LS2 9JT, United Kingdom.ORCID https://orcid.org/0000-0003-4898-2712
Gregory de BoerSchool of Mechanical Engineering, University of Leeds, Leeds LS2 9JT, United Kingdom.ORCID https://orcid.org/0000-0002-5647-1771
Stephen J RussellSchool of Design, University of Leeds, Leeds LS2 9JT, United Kingdom.
Muhammad TausifSchool of Design, University of Leeds, Leeds LS2 9JT, United Kingdom.
David R J HoseChemical Development, Pharmaceutical Technology and Development, Operations, AstraZeneca, Macclesfield SK10 2NA, United Kingdom.ORCID https://orcid.org/0000-0003-3872-7996
Anna R ParsonsChemical Development, Pharmaceutical Technology and Development, Operations, AstraZeneca, Macclesfield SK10 2NA, United Kingdom.
Alex CramptonChemical Development, Pharmaceutical Technology and Development, Operations, AstraZeneca, Macclesfield SK10 2NA, United Kingdom.
Nikil KapurSchool of Mechanical Engineering, University of Leeds, Leeds LS2 9JT, United Kingdom.ORCID https://orcid.org/0000-0003-1041-8390

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Presented here is the design and performance of a coalescing liquid-liquid filter, based on low-cost and readily available meltblown nonwoven substrates for separation of immiscible phases. The performance of the coalescer was determined across three broad classes of fluid mixtures: (i) immiscible organic/aqueous systems, (ii) a surfactant laden organic/aqueous system with modification of the type of emulsion and interfacial surface tension through the addition of sodium chloride, and (iii) a water-acetone/toluene system. The first two classes demonstrated good performance of the equipment in effecting separation, including the separation of a complex emulsion system for which a membrane separator, operating through transport of a preferentially wetting fluid through the membrane, failed entirely. The third system was used to demonstrate the performance of the separator within a multistage liquid-liquid counterflow extraction system. The performance, robust nature, and scalability of coalescing filters should mean that this approach is routinely considered for liquid-liquid separations and extractions within the fine chemical and pharmaceutical industry.

Identifiers

PMID38783854
PMCPMC11110050

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.