Evidence map›Paper›PMID 38783686›Full record

ArticleGut microbes

Incremental increases in physiological fluid shear progressively alter pathogenic phenotypes and gene expression in multidrug resistant

Jiseon Yang, Jennifer Barrila, Eric A Nauman, Seth D Nydam, Shanshan Yang, Jin Park, Ami D Gutierrez-Jensen, Christian L Castro, C Mark Ott, Kristina Buss and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Gut microbes. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Jiseon YangBiodesign Center for Fundamental and Applied Microbiomics, Arizona State University, Tempe, AZ, USA.ORCID 0000-0002-5393-7062
Jennifer BarrilaBiodesign Center for Fundamental and Applied Microbiomics, Arizona State University, Tempe, AZ, USA.
Eric A NaumanDepartment of Biomedical Engineering, University of Cincinnati, Cincinnati, OH, USA.
Seth D NydamDepartment of Animal Care & Technologies, Arizona State University, Tempe, AZ, USA.
Shanshan YangBioinformatics Core Facility, Bioscience, Knowledge Enterprise, Arizona State University, Tempe, AZ, USA.
Jin ParkBiodesign Center for Personalized Diagnostics, Arizona State University, Tempe, AZ, USA.
Ami D Gutierrez-JensenBiodesign Center for Immunotherapy, Vaccines and Virotherapy, Arizona State University, Tempe, AZ, USA.
Christian L CastroBiodesign Center for Immunotherapy, Vaccines and Virotherapy, Arizona State University, Tempe, AZ, USA.
C Mark OttBiomedical Research and Environmental Sciences Division, NASA Johnson Space Center, Houston, TX, USA.
Kristina BussBioinformatics Core Facility, Bioscience, Knowledge Enterprise, Arizona State University, Tempe, AZ, USA.
Jason SteelBioinformatics Core Facility, Bioscience, Knowledge Enterprise, Arizona State University, Tempe, AZ, USA.
Anne D ZakrajsekDepartment of Biomedical Engineering, University of Cincinnati, Cincinnati, OH, USA.
Mary M SchuffDepartment of Biomedical Engineering, University of Cincinnati, Cincinnati, OH, USA.
Cheryl A NickersonBiodesign Center for Fundamental and Applied Microbiomics, Arizona State University, Tempe, AZ, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The ability of bacteria to sense and respond to mechanical forces has important implications for pathogens during infection, as they experience wide fluid shear fluctuations in the host. However, little is known about how mechanical forces encountered in the infected host drive microbial pathogenesis. Herein, we combined mathematical modeling with hydrodynamic bacterial culture to profile transcriptomic and pathogenesis-related phenotypes of multidrug resistant

Indexed as

Drug Resistance, Multiple, BacterialPhenotypeSalmonella typhimuriumGene Expression Regulation, BacterialHumansHydrodynamicsSalmonella InfectionsStress, MechanicalTranscriptomehydrodynamic biosystems/fluid sheariNTS ST313/D23580RNA-seqRWV bioreactorSalmonellaSPI-1/SPI-4

Identifiers

PMID38783686
PMCPMC11135960

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.