Evidence map›Paper›PMID 38783536›Full record

ArticleCNS neuroscience & therapeutics2024

Mesenchymal stem cell-derived exosomes improve neurogenesis and cognitive function of mice with methamphetamine addiction: A novel treatment approach.

Solmaz Fallahi, Hamid Soltani Zangbar, Fereshteh Farajdokht, Reza Rahbarghazi, Fariba Ghiasi, Gisou Mohaddes

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In one paragraph

Article in CNS neuroscience & therapeutics, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 14 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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  3. Isoquinoline alkaloids inChinese herbal medicines · 2026
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors.

Solmaz FallahiDrug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
Hamid Soltani ZangbarDepartment of Neuroscience and Cognition, Faculty of Advanced Medical Sciences, Tabriz University of Medical Sciences, Tabriz, Iran.ORCID 0000-0001-6979-0723
Fereshteh FarajdokhtDepartment of Physiology, Tabriz University of Medical Sciences, Tabriz, Iran.
Reza RahbarghaziDepartment of Applied Cell Sciences, Faculty of Advanced Medical Sciences, Tabriz University of Medical Sciences, Tabriz, Iran.
Fariba GhiasiDrug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.ORCID 0000-0002-8992-3033
Gisou MohaddesDrug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.ORCID 0000-0002-3732-1663

Funding

Drug Applied Research Center, Tabriz University of Medical Sciences 67159
6 · The paper itself

Abstract

backgroundMethamphetamine (METH) is a psychostimulant substance with highly addictive and neurotoxic effects, but no ideal treatment option exists to improve METH-induced neurocognitive deficits. Recently, mesenchymal stem cells (MSCs)-derived exosomes have raised many hopes for treating neurodegenerative sequela of brain disorders. This study aimed to determine the therapeutic potential of MSCs-derived exosomes on cognitive function and neurogenesis of METH-addicted rodents.

methodsMale BALB/c mice were subjected to chronic METH addiction, followed by intravenous administration of bone marrow MSCs-derived exosomes. Then, the spatial memory and recognition memory of animals were assessed by the Barnes maze and the novel object recognition test (NORT). The neurogenesis-related factors, including NeuN and DCX, and the expression of Iba-1, a microglial activation marker, were assessed in the hippocampus by immunofluorescence staining. Also, the expression of inflammatory cytokines, including TNF-α and NF-κB, were evaluated by western blotting.

resultsThe results showed that BMSCs-exosomes improved the time spent in the target quadrant and correct-to-wrong relative time in the Barnes maze. Also, NORT's discrimination index (DI) and recognition index (RI) were improved following exosome therapy. Additionally, exosome therapy significantly increased the expression of NeuN and DCX in the hippocampus while decreasing the expression of inflammatory cytokines, including TNF-α and NF-κB. Besides, BMSC-exosomes down-regulated the expression of Iba-1.

conclusionOur findings indicate that BMSC-exosomes mitigated METH-caused cognitive dysfunction by improving neurogenesis and inhibiting neuroinflammation in the hippocampus.

Indexed as

Amphetamine-Related DisordersDoublecortin ProteinExosomesHippocampusMesenchymal Stem CellsMethamphetamineMice, Inbred BALB CNeurogenesisAnimalsCalcium-Binding ProteinsCentral Nervous System StimulantsCognitionDNA-Binding ProteinsMaleMaze LearningMesenchymal Stem Cell TransplantationAif1 protein, mouseCalcium-Binding ProteinsCentral Nervous System StimulantsDcx protein, mouseDNA-Binding ProteinsDoublecortin ProteinMethamphetamineMicrofilament ProteinsNerve Tissue ProteinsNeuN protein, mouseaddictionbone marrow mesenchymal stem cellscognitionexosomemethamphetamineneurogenesisneuroinflammation

Identifiers

PMID38783536
PMCPMC11116483

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.