Evidence map›Paper›PMID 38783368›Full record

ArticleCancer & metabolism2024

Disrupting Na

Aidan M Michaels, Anna Zoccarato, Zoe Hoare, George Firth, Yu Jin Chung, Philip W Kuchel, Ajay M Shah, Michael J Shattock, Richard Southworth, Thomas R Eykyn

Abstract read
In one paragraph

Article in Cancer & metabolism, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
  4. Article
  5. Article
  6. Review
  7. Inhibition of NaBiomedical engineering online · 2025
    Article
  8. Article
  9. Review
  10. Article
  11. Article
  12. Review
  13. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Aidan M MichaelsSchool of Biomedical Engineering and Imaging Sciences, King's College London, St Thomas' Hospital, London, SE1 7EH, UK.
Anna ZoccaratoSchool of Cardiovascular and Metabolic Medicine and Sciences, King's College London, London, UK.
Zoe HoareSchool of Cardiovascular and Metabolic Medicine and Sciences, King's College London, London, UK.
George FirthSchool of Biomedical Engineering and Imaging Sciences, King's College London, St Thomas' Hospital, London, SE1 7EH, UK.
Yu Jin ChungSchool of Cardiovascular and Metabolic Medicine and Sciences, King's College London, London, UK.
Philip W KuchelSchool of Life and Environmental Sciences, University of Sydney, Sydney, NSW, 2006, Australia.
Ajay M ShahSchool of Cardiovascular and Metabolic Medicine and Sciences, King's College London, London, UK.
Michael J ShattockSchool of Cardiovascular and Metabolic Medicine and Sciences, King's College London, London, UK.
Richard SouthworthSchool of Biomedical Engineering and Imaging Sciences, King's College London, St Thomas' Hospital, London, SE1 7EH, UK.
Thomas R EykynSchool of Biomedical Engineering and Imaging Sciences, King's College London, St Thomas' Hospital, London, SE1 7EH, UK. thomas.eykyn@kcl.ac.uk.

Funding

Australian Research Council DP190100510British Heart Foundation RE/18/2/34213Engineering and Physical Sciences Research Council EP/S022104/1Wellcome TrustWellcome Trust and EPSRC WT 203148/Z/16/Z
6 · The paper itself

Abstract

backgroundGlycolytic flux is regulated by the energy demands of the cell. Upregulated glycolysis in cancer cells may therefore result from increased demand for adenosine triphosphate (ATP), however it is unknown what this extra ATP turnover is used for. We hypothesise that an important contribution to the increased glycolytic flux in cancer cells results from the ATP demand of Na

methodsLive whole-cell measurements of intracellular sodium [Na

resultsIntracellular [Na

conclusionsGlycolytic flux correlates with Na

Indexed as

Breast cancerGlycolysisIntracellular sodiumNaK ATPaseOuabainWarburg effect

Identifiers

PMID38783368
PMCPMC11119389

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.