Evidence map›Paper›PMID 38783321›Full record

ArticleArthritis research & therapy2024

Causal relationship between rheumatoid arthritis and bronchiectasis: a bidirectional mendelian randomization study.

Zehu Chen, Xuegang Li, Honglei Shi, Yiying Huang, Jing Liu

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Article in Arthritis research & therapy, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.

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4citing papers in PubMed, 1 pooled it
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1 · What the graph read from it

What it found

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3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it.

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4 · The record

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5 · Who and what money

Authors and funding

5 authors.

Zehu Chen *Department of Respiratory and Critical Care Medicine, the Fifth Affiliated Hospital of Sun Yat-sen University, Zhuhai, China.
Xuegang Li *Department of Rheumatology, the Fifth Affiliated Hospital of Sun Yat-sen University, Zhuhai, China.
Honglei Shi *Department of Respiratory and Critical Care Medicine, Affiliated Beijing Chaoyang Hospital of Capital Medical University, Beijing, China.
Yiying HuangDepartment of Respiratory and Critical Care Medicine, the Fifth Affiliated Hospital of Sun Yat-sen University, Zhuhai, China. huangyyn@mail2.sysu.edu.cn.
Jing LiuDepartment of Respiratory and Critical Care Medicine, the Fifth Affiliated Hospital of Sun Yat-sen University, Zhuhai, China. liujing25@mail.sysu.edu.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundEpidemiological observational studies have elucidated a correlation between rheumatoid arthritis (RA) and bronchiectasis. However, the causal nature of this association remains ambiguous. To clarify this potential causal linkage, we conducted a two-sample Mendelian randomization (MR) analysis to explore the bidirectional causality between RA and bronchiectasis.

methodsSummary statistics for RA and bronchiectasis were obtained from the IEU OpenGWAS database We employed various methods, including inverse variance weighting (IVW), MR-Egger, weighted median, weighted mode, and simple mode, to explore potential causal links between RA and bronchiectasis. Additionally, a series of sensitivity studies, such as Cochran's Q test, MR Egger intercept test, and leave-one-out analysis, were conducted to assess the MR analysis's accuracy further.

resultsIn the forward MR analysis, the primary analysis indicated that a genetic predisposition to RA correlated with an increased risk of bronchiectasis in European populations (IVW odds ratio (OR): 1.28, 95% confidence interval (CI): 1.20-1.37, p = 1.18E-13). Comparable results were noted in the East Asian subjects (IVW OR: 1.55, 95% CI: 1.30-1.34, p = 8.33E-07). The OR estimates from the other four methods were consistent with those obtained from the IVW method. Sensitivity analysis detected no evidence of horizontal pleiotropy or heterogeneity. Conversely, in the reverse MR analysis, we found no evidence to support a genetic causality between bronchiectasis and RA in either European or East Asian populations.

conclusionThis study indicates that genetic predisposition to RA correlates with a heightened risk of bronchiectasis in both European and East Asian populations. These results imply that routine screening for bronchiectasis in RA patients could be beneficial, and effective management of RA may contribute to a reduced risk of bronchiectasis. Future research should aim to clarify the underlying mechanisms linking these two conditions.

Indexed as

Arthritis, RheumatoidBronchiectasisGenetic Predisposition to DiseaseMendelian Randomization AnalysisCausalityEast Asian PeopleHumansPolymorphism, Single NucleotideRisk FactorsWhite PeopleBronchiectasisGenome-wide association studyMendelian randomizationRheumatoid arthritisSingle-nucleotide polymorphisms

Identifiers

PMID38783321
PMCPMC11112812

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