Evidence map›Paper›PMID 38783307›Full record

ArticleGenome biology2024

Identification of the RSX interactome in a marsupial shows functional coherence with the Xist interactome during X inactivation.

Kim L McIntyre, Shafagh A Waters, Ling Zhong, Gene Hart-Smith, Mark Raftery, Zahra A Chew, Hardip R Patel, Jennifer A Marshall Graves, Paul D Waters

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Genome biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Metamorphosis and lncRNAs: A Close Relationship.Genesis (New York, N.Y. : 2000) · 2026
    Review
  2. Review
  3. Article
  4. Compensation of gene dosage on the mammalian X.Development (Cambridge, England) · 2024
    Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Kim L McIntyre *School of Biotechnology and Biomolecular Sciences, University of New South Wales, Sydney, NSW, 2052, Australia.
Shafagh A Waters *School of Biomedical Sciences, Faculty of Medicine and Health, University of New South Wales, Sydney, NSW, 2052, Australia.
Ling ZhongBioanalytical Mass Spectrometry Facility, University of New South Wales, Sydney, NSW, 2052, Australia.
Gene Hart-SmithAustralian Proteome Analysis Facility, Macquarie University, Macquarie Park, NSW, Australia.
Mark RafteryBioanalytical Mass Spectrometry Facility, University of New South Wales, Sydney, NSW, 2052, Australia.
Zahra A ChewNational Centre for Indigenous Genomics, Australian National University, Canberra, ACT, 2601, Australia.
Hardip R PatelNational Centre for Indigenous Genomics, Australian National University, Canberra, ACT, 2601, Australia.
Jennifer A Marshall GravesDepartment of Environment and Genetics, La Trobe University, Melbourne, VIC, 3086, Australia.
Paul D WatersSchool of Biotechnology and Biomolecular Sciences, University of New South Wales, Sydney, NSW, 2052, Australia. p.waters@unsw.edu.au.ORCID 0000-0002-4689-8747

Funding

Australian National Health and Medical Research Council Ideas Grant 1188987Australian Research Council Discovery Projects DP170101147Australian Research Council Discovery Projects DP180100931Australian Research Council Discovery Projects DP210103512Australian Research Council Discovery Projects DP220101429National Health and Medical Research Council 2021172NHMRC Ideas Grant 2021172NHMRC Ideas Grant 2027730
6 · The paper itself

Abstract

The marsupial specific RSX lncRNA is the functional analogue of the eutherian specific XIST, which coordinates X chromosome inactivation. We characterized the RSX interactome in a marsupial representative (the opossum Monodelphis domestica), identifying 135 proteins, of which 54 had orthologues in the XIST interactome. Both interactomes were enriched for biological pathways related to RNA processing, regulation of translation, and epigenetic transcriptional silencing. This represents a remarkable example showcasing the functional coherence of independently evolved lncRNAs in distantly related mammalian lineages.

Indexed as

RNA, Long NoncodingX Chromosome InactivationAnimalsMonodelphisRNA, Long NoncodingXIST non-coding RNAConvergent evolutionRSX protein interactomeX chromosome inactivation

Identifiers

PMID38783307
PMCPMC11112854

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.