Evidence map›Paper›PMID 38783266›Full record

ArticleBMC psychiatry2024

Gender differences in plasma S100B levels of patients with major depressive disorder.

Yifan Wu, Yihui Lu, Lingtao Kong, Yu Xie, Wen Liu, Anqi Yang, Kaiqi Xin, Xintong Yan, Longhai Wu, Yilin Liu and 6 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC psychiatry, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Yifan WuDepartment of Psychiatry, The First Hospital of China Medical University, 155 Nanjing North Street, 110001, Liaoning, P.R. China.
Yihui LuDepartment of Psychiatry, The First Hospital of China Medical University, 155 Nanjing North Street, 110001, Liaoning, P.R. China.
Lingtao KongDepartment of Psychiatry, The First Hospital of China Medical University, 155 Nanjing North Street, 110001, Liaoning, P.R. China.
Yu XieFaculty of Public Health, China Medical University, 110001, Liaoning, P.R. China.
Wen LiuDepartment of Psychiatry, The First Hospital of China Medical University, 155 Nanjing North Street, 110001, Liaoning, P.R. China.
Anqi YangDepartment of Psychiatry, The First Hospital of China Medical University, 155 Nanjing North Street, 110001, Liaoning, P.R. China.
Kaiqi XinDepartment of Psychiatry, The First Hospital of China Medical University, 155 Nanjing North Street, 110001, Liaoning, P.R. China.
Xintong YanDepartment of Psychiatry, The First Hospital of China Medical University, 155 Nanjing North Street, 110001, Liaoning, P.R. China.
Longhai WuDepartment of Psychiatry, The First Hospital of China Medical University, 155 Nanjing North Street, 110001, Liaoning, P.R. China.
Yilin LiuDepartment of Psychiatry, The First Hospital of China Medical University, 155 Nanjing North Street, 110001, Liaoning, P.R. China.
Qianying ZhuDepartment of Psychiatry, The First Hospital of China Medical University, 155 Nanjing North Street, 110001, Liaoning, P.R. China.
Yang CaoShenyang Mental Health Center, 110001, Liaoning, P.R. China.
Yifang ZhouDepartment of Psychiatry, The First Hospital of China Medical University, 155 Nanjing North Street, 110001, Liaoning, P.R. China.
Xiaowei JiangBrain Function Research Section, Department of Radiology, The First Hospital of China Medical University, 110001, Liaoning, P.R. China.
Yanqing TangDepartment of Psychiatry, The First Hospital of China Medical University, 155 Nanjing North Street, 110001, Liaoning, P.R. China.
Feng WuDepartment of Psychiatry, The First Hospital of China Medical University, 155 Nanjing North Street, 110001, Liaoning, P.R. China. wufeng@cmu.edu.cn.

Funding

Liaoning Revitalization Talents Program XLYC1808036National Key Research and Development Program of China 2018YFC1311600National Key Research and Development Program of China 2021YFF0306503National Natural Science Foundation of China 2019-MS-05National Natural Science Foundation of China-Liaoning Joint Fund U1808204Natural Science Foundation of Liaoning Province 2020-MS-176Natural Science Foundation of Liaoning Province 2022-YGJC-40
6 · The paper itself

Abstract

backgroundLow concentrations of S100B have neurotrophic effects and can promote nerve growth and repair, which plays an essential role in the pathophysiological and histopathological alterations of major depressive disorder (MDD) during disease development. Studies have shown that plasma S100B levels are altered in patients with MDD. In this study, we investigated whether the plasma S100B levels in MDD differ between genders.

methodsWe studied 235 healthy controls (HCs) (90 males and 145 females) and 185 MDD patients (65 males and 120 females). Plasma S100B levels were detected via multifactor assay. The Mahalanobis distance method was used to detect the outliers of plasma S100B levels in the HC and MDD groups. The Kolmogorov-Smirnov test was used to test the normality of six groups of S100B samples. The Mann-Whitney test and Scheirer-Ray-Hare test were used for the comparison of S100B between diagnoses and genders, and the presence of a relationship between plasma S100B levels and demographic details or clinical traits was assessed using Spearman correlation analysis.

resultsAll individuals in the HC group had plasma S100B levels that were significantly greater than those in the MDD group. In the MDD group, males presented significantly higher plasma S100B levels than females. In the male group, the plasma S100B levels in the HC group were significantly higher than those in the MDD group, while in the female group, no significant difference was found between the HC and MDD groups. In the male MDD subgroup, there was a positive correlation between plasma S100B levels and years of education. In the female MDD subgroup, there were negative correlations between plasma S100B levels and age and suicidal ideation.

conclusionsIn summary, plasma S100B levels vary with gender and are decreased in MDD patients, which may be related to pathological alterations in glial cells.

Indexed as

Major Depressive DisorderS100 Calcium Binding Protein beta SubunitAdultBiomarkersCase-Control StudiesFemaleHumansMaleMiddle AgedSex CharacteristicsSex FactorsBiomarkersS100B protein, humanS100 Calcium Binding Protein beta SubunitGender differenceGlial cellsMajor depressive disorderMann–Whitney testPlasma S100BScheirer-Ray-Hare test

Identifiers

PMID38783266
PMCPMC11112965

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.