Evidence map›Paper›PMID 38783230›Full record

ArticleBMC ophthalmology2024

Decrease in electrolyte after vitrectomy surgery may affect the results of forensic investigations using vitreous humor.

Hiroaki Ushida, Ayana Suzumura, Kazuhisa Yamada, Hideyuki Shimizu, Atsuo Suzuki, Yusuke Ishikawa, Ryosuke Kikuchi, Koji M Nishiguchi, Hiroki Kaneko

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In one paragraph

Article in BMC ophthalmology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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4 · The record

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5 · Who and what money

Authors and funding

9 authors.

Hiroaki UshidaDepartment of Ophthalmology, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, 466-8550, Nagoya, Japan.
Ayana SuzumuraDepartment of Ophthalmology, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, 466-8550, Nagoya, Japan.
Kazuhisa YamadaDepartment of Ophthalmology, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, 466-8550, Nagoya, Japan.
Hideyuki ShimizuDepartment of Ophthalmology, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, 466-8550, Nagoya, Japan.
Atsuo SuzukiDepartment of Clinical Laboratory, Nagoya University Hospital, 65 Tsurumai-cho, Showa-ku, 466-8550, Nagoya, Japan.
Yusuke IshikawaDepartment of Clinical Laboratory, Nagoya University Hospital, 65 Tsurumai-cho, Showa-ku, 466-8550, Nagoya, Japan.
Ryosuke KikuchiDivision of Clinical Laboratory, Gifu University Hospital, 1-1 Yanagido, 501-1194, Gifu City, Japan.
Koji M NishiguchiDepartment of Ophthalmology, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, 466-8550, Nagoya, Japan.
Hiroki KanekoDepartment of Ophthalmology, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, 466-8550, Nagoya, Japan. h-kaneko@med.nagoya-u.ac.jp.

Funding

Grants-in-Aid for Scientific Research C 22K09810Grants-in-Aid for Scientific Research for young scientist 22K16949Grants-in-Aid for Scientific Research for young scientist 22K16968
6 · The paper itself

Abstract

purposeVitreous humor (VH) is used for postmortem biochemical studies because it is well protected in an uncontaminated state even after death. The goal of this research was to investigate electrolyte concentrations in the VH from human eyes with and without a history of vitrectomy surgery.

methodsWe analyzed the sodium (Na), potassium (K), chloride (Cl) and magnesium (Mg) concentrations from 34 VH samples from 34 patients. Eleven samples were from eyes with a history of vitrectomy, and the remaining 23 eyes had no history of vitrectomy. The correlations of Na, K, Cl and Mg concentrations with patient age, interval between first and second vitrectomy, and lens status (history of cataract surgery) were also evaluated.

resultsThe Na, K, Cl and Mg concentrations in VH from vitrectomized eyes were 134.1 ± 7.9 mmol/L, 3.7 ± 0.2 mmol/L, 99.7 ± 6.7 mmol/L and 0.59 ± 0.09 mmol/L, respectively; all were significantly lower than the corresponding concentrations in VH from control eyes (lower by 5.0%, 11.0%, 11.7%, and 22.6%, respectively). Na, K, Cl and Mg concentrations in VH from vitrectomized eyes did not show significant correlations with patient ages or the interval between their first and second vitrectomies. There were no significant differences in Na, K, Cl and Mg concentrations in VH between phakic eyes and intraocular lens-implanted eyes.

conclusionsWith the increasing number of vitrectomies being performed, it is necessary to consider the history of vitrectomy when using a subject's VH in forensic examination.

Indexed as

VitrectomyVitreous BodyAdultAgedAged, 80 and overElectrolytesFemaleForensic MedicineHumansMagnesiumMaleMiddle AgedPotassiumSodiumElectrolytesMagnesiumPotassiumSodiumCataract surgeryForensic investigationIntravitreal electrolytesPostmortem intervalVitrectomy surgery

Identifiers

PMID38783230
PMCPMC11118106

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.