Evidence map›Paper›PMID 38783208›Full record

Observational studyBMC gastroenterology2024

Outcome of patients with perihilar cholangiocarcinoma and previous biliary instrumentation: an observational study.

Karen T Brown, Joanne F Chou, Hannah B Suchy, George I Getrajdman, Mithat Gonen, Anne M Covey, Lynn A Brody, Mark A Schattner, Michael I D'Angelica, T Peter Kingham and 2 more

Abstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in BMC gastroenterology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Karen T BrownDepartment of Radiology, New York-Presbyterian Hospital, New York, NY, USA. sxa9001@med.cornell.edu.
Joanne F ChouDepartment of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Hannah B SuchyDepartment of Radiology, New York-Presbyterian Hospital, New York, NY, USA.
George I GetrajdmanDepartment of Radiology, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Mithat GonenDepartment of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Anne M CoveyDepartment of Radiology, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Lynn A BrodyDepartment of Radiology, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Mark A SchattnerDivision of Gastroenterology, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Michael I D'AngelicaHepatopancreaticobiliary Surgery Division, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
T Peter KinghamHepatopancreaticobiliary Surgery Division, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Joseph P ErinjeriDepartment of Radiology, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
William R JarnaginHepatopancreaticobiliary Surgery Division, Memorial Sloan Kettering Cancer Center, New York, NY, USA.

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Nicholas D Socci · 1985 to 2026
$347.4M
NCI NIH HHS P30 CA008748
6 · The paper itself

Abstract

backgroundTo assess the outcome of previously untreated patients with perihilar cholangiocarcinoma who present to a cancer referral center with or without pre-existing trans-papillary biliary drainage.

methodsConsecutive patients with a diagnosis of perihilar cholangiocarcinoma presenting between January 1, 2013, and December 31, 2017, were identified from a prospective surgical database and by a query of the institutional database. Of 237 patients identified, 106 met inclusion criteria and were reviewed. Clinical information was obtained from the Electronic Medical Record and imaging studies were reviewed in the Picture Archiving and Communication System.

results73 of 106 patients (69%) presenting with a new diagnosis of perihilar cholangiocarcinoma underwent trans-papillary biliary drainage (65 endoscopic and 8 percutaneous) prior to presentation at our institution. 8 of the 73 patients with trans-papillary biliary drainage (11%) presented with and 5 developed cholangitis; all 13 (18%) required subsequent intervention; none of the patients without trans-papillary biliary drainage presented with or required drainage for cholangitis (p = 0.008). Requiring drainage for cholangitis was more likely to delay treatment (p = 0.012) and portended a poorer median overall survival (13.6 months, 95%CI [4.08, not reached)] vs. 20.6 months, 95%CI [18.34, 37.51] p = 0.043).

conclusionTrans-papillary biliary drainage for perihilar cholangiocarcinoma carries a risk of cholangitis and should be avoided when possible. Clinical and imaging findings of perihilar cholangiocarcinoma should prompt evaluation at a cancer referral center before any intervention. This would mitigate development of cholangitis necessitating additional drainage procedures, delaying treatment and potentially compromising survival.

Indexed as

Bile Duct NeoplasmsDrainageKlatskin TumorAdultAgedAged, 80 and overCholangitisFemaleHumansMaleMiddle AgedRetrospective StudiesTreatment OutcomeBile duct cancerBiliary stentEndoscopic stentPeri-hilar cholangiocarcinoma

Identifiers

PMID38783208
PMCPMC11118511

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.