Evidence map›Paper›PMID 38783079›Full record

ArticleNucleic acids research2024

Next-generation IEDB tools: a platform for epitope prediction and analysis.

Zhen Yan, Kevin Kim, Haeuk Kim, Brendan Ha, Anaïs Gambiez, Jason Bennett, Marcus Fabiano de Almeida Mendes, Raphael Trevizani, Jarjapu Mahita, Eve Richardson and 7 more

Abstract read
In one paragraph

Article in Nucleic acids research, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
48citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

48 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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  7. Review
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  16. Molecular origin, discovery, validation and application of neoantigens.Asian journal of pharmaceutical sciences · 2026
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Zhen YanBioinformatics Core, La Jolla Institute for Immunology, La Jolla, CA 92037, USA.
Kevin KimInformation Technology, La Jolla Institute for Immunology, La Jolla, CA 92037, USA.
Haeuk KimBioinformatics Core, La Jolla Institute for Immunology, La Jolla, CA 92037, USA.
Brendan HaBioinformatics Core, La Jolla Institute for Immunology, La Jolla, CA 92037, USA.
Anaïs GambiezBioinformatics Core, La Jolla Institute for Immunology, La Jolla, CA 92037, USA.
Jason BennettCenter for Vaccine Innovation, La Jolla Institute for Immunology, La Jolla, CA 92037, USA.
Marcus Fabiano de Almeida MendesCenter for Vaccine Innovation, La Jolla Institute for Immunology, La Jolla, CA 92037, USA.
Raphael TrevizaniCenter for Vaccine Innovation, La Jolla Institute for Immunology, La Jolla, CA 92037, USA.
Jarjapu MahitaCenter for Vaccine Innovation, La Jolla Institute for Immunology, La Jolla, CA 92037, USA.
Eve RichardsonCenter for Vaccine Innovation, La Jolla Institute for Immunology, La Jolla, CA 92037, USA.
Daniel MarramaCenter for Vaccine Innovation, La Jolla Institute for Immunology, La Jolla, CA 92037, USA.
Nina BlazeskaCenter for Vaccine Innovation, La Jolla Institute for Immunology, La Jolla, CA 92037, USA.
Zeynep Koşaloğlu-YalçınCenter for Vaccine Innovation, La Jolla Institute for Immunology, La Jolla, CA 92037, USA.ORCID 0000-0003-0961-5055
Morten NielsenDepartment of Health Technology, Technical University of Denmark, DK-2800 Kgs, Lyngby, Denmark.ORCID 0000-0001-7885-4311
Alessandro SetteCenter for Vaccine Innovation, La Jolla Institute for Immunology, La Jolla, CA 92037, USA.
Bjoern PetersCenter for Vaccine Innovation, La Jolla Institute for Immunology, La Jolla, CA 92037, USA.ORCID 0000-0002-8457-6693
Jason A GreenbaumBioinformatics Core, La Jolla Institute for Immunology, La Jolla, CA 92037, USA.ORCID 0000-0002-1381-0390

Funding

IMMUNE EPITOPE AND ANALYSIS PROGRAM: Transplantation of organs, tissues and cells 75N93019C00001 · NIAID · LA JOLLA INSTITUTE FOR IMMUNOLOGY · PI WILSON, STEPHEN · 2019 to 2025
$23.1M
THE CANCER EPITOPE DATABASE AND ANALYSIS RESOURCEU24CA248138 · NCI · LA JOLLA INSTITUTE FOR IMMUNOLOGY · PI PETERS, BJOERN, SETTE, ALESSANDRO · 2021 to 2025
$4.6M
CEDARIEDBNCI NIH HHS U24 CA248138NIH HHS 75N93019C00001
6 · The paper itself

Abstract

The Next-Generation (NG) IEDB Tools website (https://nextgen-tools.iedb.org) provides users with a redesigned interface to many of the algorithms for epitope prediction and analysis that were originally released on the legacy IEDB Tools website. The initial release focuses on consolidation of all tools related to HLA class I epitopes (MHC binding, elution, immunogenicity, and processing), making all of these predictions accessible from a single application and allowing for their simultaneous execution with minimal user inputs. Additionally, the PEPMatch tool for identifying highly similar epitopes in a set of curated proteomes, as well as a tool for epitope clustering, are available on the site. The NG Tools site allows users to build data pipelines by sending the output of one tool as input for the next. Over the next several years, all pre-existing IEDB Tools, and any newly developed tools, will be integrated into this new site. Here we describe the philosophy behind the redesign and demonstrate the utility and productivity enhancements that are enabled by the new interface.

Indexed as

AlgorithmsEpitopesSoftwareDatabases, ProteinHistocompatibility Antigens Class IHumansInternetEpitopesHistocompatibility Antigens Class I

Identifiers

PMID38783079
PMCPMC11223806

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.