Evidence map›Paper›PMID 38782965›Full record

ArticleScientific reports2024

FAT1 inhibits the proliferation of DLBCL cells via increasing the m

Tian-Long Wang, Xiao-Juan Miao, Yan-Rong Shuai, Hao-Ping Sun, Xiao Wang, Min Yang, Nan Zhang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Tian-Long Wang *Department of Medical, People's Liberation Army The General Hospital of Western Theater Command, Chengdu, 610083, China.
Xiao-Juan Miao *Department of Hematology, People's Liberation Army The General Hospital of Western Theater Command, Sichuan Clinical Research Center for Hematological Disease, Branch of National Clinical Research Center for Hematological Disease, Chengdu, 610083, China.
Yan-Rong Shuai *Department of Hematology, People's Liberation Army The General Hospital of Western Theater Command, Sichuan Clinical Research Center for Hematological Disease, Branch of National Clinical Research Center for Hematological Disease, Chengdu, 610083, China.
Hao-Ping SunDepartment of Hematology, People's Liberation Army The General Hospital of Western Theater Command, Sichuan Clinical Research Center for Hematological Disease, Branch of National Clinical Research Center for Hematological Disease, Chengdu, 610083, China.
Xiao WangDepartment of Hematology, People's Liberation Army The General Hospital of Western Theater Command, Sichuan Clinical Research Center for Hematological Disease, Branch of National Clinical Research Center for Hematological Disease, Chengdu, 610083, China. xxwx@foxmail.com.
Min YangDepartment of Traditional Chinese Medicine, People's Liberation Army The General Hospital of Western Theater Command, Chengdu, 610083, China. translie@live.cn.
Nan ZhangDepartment of Hematology, People's Liberation Army The General Hospital of Western Theater Command, Sichuan Clinical Research Center for Hematological Disease, Branch of National Clinical Research Center for Hematological Disease, Chengdu, 610083, China. zhangnandr@163.com.

Funding

People's Liberation Army The General Hospital of Western Theater Command 2021-XZYG-A08People's Liberation Army The General Hospital of Western Theater Command 2021-XZYG-B34Science and Technology Department of Sichuan Province 2022NSFSC1330Science and Technology Department of Sichuan Province 2023NSFSC0528
6 · The paper itself

Abstract

Emerging evidence shows that FAT atypical cadherin 1 (FAT1) mutations occur in lymphoma and are associated with poorer overall survival. Considering that diffuse large B cell lymphoma (DLBCL) is the category of lymphoma with the highest incidence rate, this study aims to explore the role of FAT1 in DLBCL. The findings demonstrate that FAT1 inhibits the proliferation of DLBCL cell lines by downregulating the expression of YAP1 rather than by altering its cellular localization. Mechanistic analysis via meRIP-qPCR/luciferase reporter assays showed that FAT1 increases the m

Indexed as

3' Untranslated RegionsAdaptor Proteins, Signal TransducingCell ProliferationGene Expression Regulation, NeoplasticLymphoma, Large B-Cell, DiffuseRNA, MessengerTranscription FactorsYAP-Signaling ProteinsAdenosineCadherinsCell Line, TumorHumansSignal Transduction3' Untranslated RegionsAdaptor Proteins, Signal TransducingAdenosineCadherinsFAT1 protein, humanN-methyladenosineRNA, MessengerTranscription FactorsYAP1 protein, humanYAP-Signaling ProteinsALKBH5Diffuse large B cell lymphoma (DLBCL)FAT atypical cadherin 1 (FAT1)Heterogeneous nuclear ribonucleoprotein D (HNRNPD)m6AYes1 associated transcriptional regulator (YAP1)

Identifiers

PMID38782965
PMCPMC11116375

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.