Evidence map›Paper›PMID 38782917›Full record

ArticleNature communications2024

Heat-activated growth of metastable and length-defined DNA fibers expands traditional polymer assembly.

Michael D Dore, Muhammad Ghufran Rafique, Tianxiao Peter Yang, Marlo Zorman, Casey M Platnich, Pengfei Xu, Tuan Trinh, Felix J Rizzuto, Gonzalo Cosa, Jianing Li and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Review
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Michael D Dore *Department of Chemistry, McGill University, 801 Sherbrooke St W, Montréal, QC, H3A 08B, Canada.ORCID http://orcid.org/0000-0002-9721-3189
Muhammad Ghufran Rafique *Department of Chemistry, McGill University, 801 Sherbrooke St W, Montréal, QC, H3A 08B, Canada.ORCID http://orcid.org/0000-0003-4394-184X
Tianxiao Peter YangDepartment of Biochemistry and Centre de Recherche en Biologie Structurale, McGill University, Montréal, QC, Canada.
Marlo ZormanDepartment of Chemistry, University of Vermont, Burlington, VT, 05405, USA.
Casey M PlatnichDepartment of Chemistry, McGill University, 801 Sherbrooke St W, Montréal, QC, H3A 08B, Canada.
Pengfei XuDepartment of Chemistry, McGill University, 801 Sherbrooke St W, Montréal, QC, H3A 08B, Canada.
Tuan TrinhDepartment of Chemistry, McGill University, 801 Sherbrooke St W, Montréal, QC, H3A 08B, Canada.ORCID http://orcid.org/0000-0002-0074-9746
Felix J RizzutoSchool of Chemistry, University of New South Wales, Sydney, NSW, 2052, Australia.ORCID http://orcid.org/0000-0003-2799-903X
Gonzalo CosaDepartment of Chemistry, McGill University, 801 Sherbrooke St W, Montréal, QC, H3A 08B, Canada.ORCID http://orcid.org/0000-0003-0064-1345
Jianing LiDepartment of Medicinal Chemistry and Molecular Pharmacology, Purdue University, West Lafayette, IN, 47906, USA.ORCID http://orcid.org/0000-0002-0143-8894
Alba GuarnéDepartment of Biochemistry and Centre de Recherche en Biologie Structurale, McGill University, Montréal, QC, Canada.ORCID http://orcid.org/0000-0003-4906-9132
Hanadi F SleimanDepartment of Chemistry, McGill University, 801 Sherbrooke St W, Montréal, QC, H3A 08B, Canada. hanadi.sleiman@mcgill.ca.ORCID http://orcid.org/0000-0002-5100-0532

Funding

Precision Design of Antimicrobial Peptides Against Bacterial InfectionsR01GM143370 · NIGMS · PURDUE UNIVERSITY · PI LI, JIANING · 2022 to 2025
$1.2M
Canadian Network for Research and Innovation in Machining Technology, Natural Sciences and Engineering Research Council of Canada (NSERC Canadian Network for Research and Innovation in Machining Technology) RGPIN-2017-05828NIGMS NIH HHS R01 GM143370
6 · The paper itself

Abstract

Biopolymers such as nucleic acids and proteins exhibit dynamic backbone folding, wherein site-specific intramolecular interactions determine overall structure. Proteins then hierarchically assemble into supramolecular polymers such as microtubules, that are robust yet dynamic, constantly growing or shortening to adjust to cellular needs. The combination of dynamic, energy-driven folding and growth with structural stiffness and length control is difficult to achieve in synthetic polymer self-assembly. Here we show that highly charged, monodisperse DNA-oligomers assemble via seeded growth into length-controlled supramolecular fibers during heating; when the temperature is lowered, these metastable fibers slowly disassemble. Furthermore, the specific molecular structures of oligomers that promote fiber formation contradict the typical theory of block copolymer self-assembly. Efficient curling and packing of the oligomers - or 'curlamers' - determine morphology, rather than hydrophobic to hydrophilic ratio. Addition of a small molecule stabilises the DNA fibers, enabling temporal control of polymer lifetime and underscoring their potential use in nucleic-acid delivery, stimuli-responsive biomaterials, and soft robotics.

Indexed as

DNAHot TemperaturePolymersHydrophobic and Hydrophilic InteractionsDNAPolymers

Identifiers

PMID38782917
PMCPMC11116425

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.