Evidence map›Paper›PMID 38782879›Full record

ArticleCardiovascular engineering and technology2024

In silico Mechanics of Stem Cells Intramyocardially Transplanted with a Biomaterial Injectate for Treatment of Myocardial Infarction.

Y D Motchon, K L Sack, M S Sirry, N J Nchejane, T Abdalrahman, J Nagawa, M Kruger, E Pauwels, D Van Loo, A De Muynck and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cardiovascular engineering and technology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Frontiers in bioengineering and biotechnology · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Y D MotchonBiomedical Engineering Research Centre, Division of Biomedical Engineering, Department of Human Biology, University of Cape Town, Observatory, South Africa. Dodzi.Motchon@uct.ac.za.ORCID 0000-0002-6222-3483
K L SackBiomedical Engineering Research Centre, Division of Biomedical Engineering, Department of Human Biology, University of Cape Town, Observatory, South Africa.ORCID 0000-0002-8253-1504
M S SirryBiomedical Engineering Research Centre, Division of Biomedical Engineering, Department of Human Biology, University of Cape Town, Observatory, South Africa.ORCID 0000-0003-3735-0963
N J NchejaneBiomedical Engineering Research Centre, Division of Biomedical Engineering, Department of Human Biology, University of Cape Town, Observatory, South Africa.ORCID 0000-0003-3983-7476
T AbdalrahmanBiomedical Engineering Research Centre, Division of Biomedical Engineering, Department of Human Biology, University of Cape Town, Observatory, South Africa.ORCID 0000-0002-0320-811X
J NagawaBiomedical Engineering Research Centre, Division of Biomedical Engineering, Department of Human Biology, University of Cape Town, Observatory, South Africa.ORCID 0000-0002-3712-9647
M KrugerCardiovascular Research Unit, University of Cape Town, Observatory, South Africa.
E PauwelsCentre for X-ray Tomography, Department of Physics and Astronomy, Ghent University, Ghent, Belgium.ORCID 0000-0002-3296-8011
D Van LooCentre for X-ray Tomography, Department of Physics and Astronomy, Ghent University, Ghent, Belgium.ORCID 0000-0001-6127-1996
A De MuynckCentre for X-ray Tomography, Department of Physics and Astronomy, Ghent University, Ghent, Belgium.
L Van HoorebekeCentre for X-ray Tomography, Department of Physics and Astronomy, Ghent University, Ghent, Belgium.ORCID 0000-0002-1943-1359
N H DaviesCardiovascular Research Unit, University of Cape Town, Observatory, South Africa.ORCID 0000-0003-0432-4515
T FranzBiomedical Engineering Research Centre, Division of Biomedical Engineering, Department of Human Biology, University of Cape Town, Observatory, South Africa. Thomas.Franz@uct.ac.za.ORCID 0000-0002-1504-3842

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeBiomaterial and stem cell delivery are promising approaches to treating myocardial infarction. However, the mechanical and biochemical mechanisms underlying the therapeutic benefits require further clarification. This study aimed to assess the deformation of stem cells injected with the biomaterial into the infarcted heart.

methodsA microstructural finite element model of a mid-wall infarcted myocardial region was developed from ex vivo microcomputed tomography data of a rat heart with left ventricular infarct and intramyocardial biomaterial injectate. Nine cells were numerically seeded in the injectate of the microstructural model. The microstructural and a previously developed biventricular finite element model of the same rat heart were used to quantify the deformation of the cells during a cardiac cycle for a biomaterial elastic modulus (E

resultsThe transplanted cells' deformation was largest for E

conclusionsCombining the microstructural and biventricular finite element models enables quantifying micromechanics of transplanted cells in the heart. The approach offers a broader scope for in silico investigations of biomaterial and cell therapies for myocardial infarction and other cardiac pathologies.

Indexed as

Computer SimulationFinite Element AnalysisModels, CardiovascularMyocardial InfarctionAnimalsBiocompatible MaterialsDisease Models, AnimalElastic ModulusMyocardiumRatsStem Cell TransplantationX-Ray MicrotomographyBiocompatible MaterialsBiomaterial injection therapyCell mechanicsCell therapyFinite element method

Identifiers

PMID38782879
PMCPMC11582092

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.