Evidence map›Paper›PMID 38782828›Full record

Observational studySurgical endoscopy2024

Oncologic outcomes following transanal total mesorectal excision: the United States experience.

Makda Getachew Zewde, Daniel K Peyser, Allen T Yu, Antoinette Bonaccorso, Erin Moshier, Karim Alavi, Robert Goldstone, John H Marks, Justin A Maykel, Elisabeth C McLemore and 5 more

Abstract readMulticenter StudyObservational Study
PubMed Publisher
In one paragraph

Observational study in Surgical endoscopy, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Trial
  2. Article
  3. Article
  4. Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Makda Getachew ZewdeDivision of Colon and Rectal Surgery, Department of Surgery, Icahn School of Medicine at Mount Sinai, 1 Gustave L. Levy Place, New York, NY, 10029, USA.ORCID 0000-0001-6710-630X
Daniel K PeyserDivision of Colon and Rectal Surgery, Department of Surgery, Icahn School of Medicine at Mount Sinai, 1 Gustave L. Levy Place, New York, NY, 10029, USA.
Allen T YuDivision of Colon and Rectal Surgery, Department of Surgery, Icahn School of Medicine at Mount Sinai, 1 Gustave L. Levy Place, New York, NY, 10029, USA.
Antoinette BonaccorsoDivision of Colon and Rectal Surgery, Department of Surgery, Icahn School of Medicine at Mount Sinai, 1 Gustave L. Levy Place, New York, NY, 10029, USA.
Erin MoshierDepartment of Population Health Science and Policy, Icahn School of Medicine at Mount Sinai, New York, USA.
Karim AlaviDepartment of Surgery, University of Massachusetts Medical School, Worcester, USA.
Robert GoldstoneDepartment of Surgery, Massachusetts General Hospital, Boston, USA.
John H MarksDepartment of Surgery, Lankenau Institute for Medical Research, Wynnewood, USA.
Justin A MaykelDepartment of Surgery, University of Massachusetts Medical School, Worcester, USA.
Elisabeth C McLemoreDepartment of Surgery, Kaiser Permanente Los Angeles Medical Center, Los Angeles, USA.
Dana SandsDepartment of Surgery, Cleveland Clinic Florida, Weston, USA.
Scott R SteeleDepartment of Surgery, Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, Cleveland, USA.
Steven D WexnerDepartment of Surgery, Cleveland Clinic Florida, Weston, USA.
Mark WhitefordDepartment of Surgery, Providence Portland Medical Center, Portland, USA.
Patricia SyllaDivision of Colon and Rectal Surgery, Department of Surgery, Icahn School of Medicine at Mount Sinai, 1 Gustave L. Levy Place, New York, NY, 10029, USA. patricia.sylla@mountsinai.org.

Funding

THE TISCH CANCER INSTITUTE - CANCER CENTER SUPPORT GRANTP30CA196521 · NCI · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI Ramon E Parsons · 2015 to 2026
$35.4M
NCI NIH HHS P30CA196521-01
6 · The paper itself

Abstract

aimThe benefits and short-term outcomes of transanal total mesorectal excision (taTME) for rectal cancer have been demonstrated previously, but questions remain regarding the oncologic outcomes following this challenging procedure. The purpose of this study was to analyze the oncologic outcomes following taTME at high-volume centers in the USA.

methodsThis was a multicenter, retrospective observational study of 8 tertiary care centers. All consecutive taTME cases for primary rectal cancer performed between 2011 and 2020 were included. Clinical, histopathologic, and oncologic data were analyzed. Primary endpoints were rate of local recurrence, distal recurrence, 3-year disease recurrence, and 3-year overall survival. Secondary endpoints included perioperative complications and TME specimen quality.

resultsA total of 391 patients were included in the study. The median age was 57 years (IQR: 49, 66), 68% of patients were male, and the median BMI was 27.4 (IQR: 24.1, 31.0). TME specimen was complete or near complete in 94.5% of cases and the rates of positive circumferential radial margin and distal resection margin were 2.0% and 0.3%, respectively. Median follow-up time was 30.7 months as calculated using reverse-KM estimator (CI 28.1-33.8) and there were 9 cases (2.5%) of local recurrence not accounting for competing risk. The 3-year estimated rate of disease recurrence was 19% (CI 15-25%) and the 3-year estimated overall survival was 90% (CI 87-94%).

conclusionThis large multicenter study confirms the oncologic safety and perioperative benefits of taTME for rectal cancer when performed by experienced surgeons at experienced referral centers.

Indexed as

Neoplasm Recurrence, LocalRectal NeoplasmsTransanal Endoscopic SurgeryAgedFemaleHumansMaleMargins of ExcisionMiddle AgedPostoperative ComplicationsProctectomyRetrospective StudiesTreatment OutcomeUnited StatesMulticenterOncologic outcomesRectal cancerTransanal total mesorectal excision

Identifiers

PMID38782828

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.