Evidence map›Paper›PMID 38782808›Full record

Observational studyJournal of general internal medicine2024

Triglyceride-Glucose Index Associated with Future Renal Function Decline in the General Population.

Daisuke Yoshida, Shota Ikeda, Keisuke Shinohara, Masaya Kazurayama, Shinji Tanaka, Masamitsu Yamaizumi, Hirokazu Nagayoshi, Kensuke Toyama, Shintaro Kinugawa

Abstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Journal of general internal medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 1 synthesis or guideline pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Daisuke Yoshida *Department of Cardiovascular Medicine, Faculty of Medical Sciences, Kyushu University, Fukuoka, Japan.
Shota Ikeda *Department of Cardiovascular Medicine, Faculty of Medical Sciences, Kyushu University, Fukuoka, Japan.
Keisuke ShinoharaDepartment of Cardiovascular Medicine, Faculty of Medical Sciences, Kyushu University, Fukuoka, Japan. shinohara.keisuke.727@m.kyushu-u.ac.jp.ORCID 0000-0002-3084-1711
Masaya KazurayamaJA Ehime Kouseiren Checkup Center, Ehime, Japan.
Shinji TanakaJA Ehime Kouseiren Checkup Center, Ehime, Japan.
Masamitsu YamaizumiJA Ehime Kouseiren Checkup Center, Ehime, Japan.
Hirokazu NagayoshiJA Ehime Kouseiren Checkup Center, Ehime, Japan.
Kensuke ToyamaJA Ehime Kouseiren Checkup Center, Ehime, Japan.
Shintaro KinugawaDepartment of Cardiovascular Medicine, Faculty of Medical Sciences, Kyushu University, Fukuoka, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe triglyceride-glucose index (TyG index), calculated as the logarithmic product of fasting triglyceride and glucose concentrations, is recognized as a simple marker of insulin resistance. However, the association between the TyG index and future decline of renal function remains unclear in the general population.

objectiveTo investigate whether the TyG index was associated with future decline of renal function in the general population who had not progressed to chronic kidney disease stage G2.

designRetrospective longitudinal observational cohort study.

participantsIndividuals who received a population-based health checkup at JA Ehime Kouseiren Checkup Center from 2010 to 2019 (n = 134,007). Individuals without data of baseline fasting triglyceride or glucose levels, or baseline and follow-up data of estimated glomerular filtration rate (eGFR), or those with baseline eGFR < 60 mL/min/1.73 m MAIN MEASURES: Future renal function decline, defined as a ≥ 25% decrease in eGFR from baseline. KEY

resultsOf 10,758 participants, 8,076 were classified into the low TyG index group (TyG index < 8.76, 1st to 3rd quartiles) and 2,682 into the high TyG index group (TyG index ≥ 8.76, 4th quartile). The mean follow-up period was 37.8 ± 23.6 months. The incidence rates of renal function decline were 0.31 and 0.69 per 100 person-years in the low and high TyG index groups, respectively. In multivariate Cox proportional hazard models, high TyG index was significantly associated with future renal function decline (hazard ratio 2.25, 95% CI 1.40-3.60). This association was consistent across subgroups stratified by age, sex, body mass index, baseline eGFR, and diagnosed hypertension, diabetes, or dyslipidemia.

conclusionIn the general population, high TyG index was associated with future renal function decline. The TyG index may be useful in identifying individuals at high risk for future renal function decline in the setting of health checkups.

Indexed as

Blood GlucoseGlomerular Filtration RateTriglyceridesAdultAgedBiomarkersCohort StudiesDisease ProgressionFemaleHumansInsulin ResistanceKidneyLongitudinal StudiesMaleMiddle AgedRenal Insufficiency, ChronicBiomarkersBlood GlucoseTriglyceridesgeneral populationhealth checkuprenal dysfunctionTyG index

Identifiers

PMID38782808
PMCPMC11618565

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.