Evidence map›Paper›PMID 38782806›Full record

ArticleChild psychiatry and human development2026

Comparing Transdiagnostic Risk Factors: Predicting Emergence of Significant Depressive, Anxiety, and Substance Abuse Symptoms Among Juvenile Delinquents.

Robert J Klein, Damien Lekkas, Nhi D Nguyen, Nicholas C Jacobson

Abstract readComparative Study
In one paragraph

Article in Child psychiatry and human development, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Robert J KleinCenter for Technology and Behavioral Health, Dartmouth College, Hanover, USA. Klein.CognitionEmotionLab@gmail.com.
Damien LekkasCenter for Technology and Behavioral Health, Dartmouth College, Hanover, USA.
Nhi D NguyenCenter for Technology and Behavioral Health, Dartmouth College, Hanover, USA.
Nicholas C JacobsonCenter for Technology and Behavioral Health, Dartmouth College, Hanover, USA.

Funding

Treatment Development & Evaluation CoreP30DA029926 · NIDA · DARTMOUTH COLLEGE · PI Lisa A. Marsch · 2011 to 2026
$21.5M
Training in the Science of Co-Occurring DisordersT32DA037202 · NIDA · DARTMOUTH COLLEGE · PI Lisa A. Marsch · 2014 to 2026
$4.7M
NIDA NIH HHS P30 DA029926NIDA NIH HHS T32 DA037202
6 · The paper itself

Abstract

In a 7-year 11-wave study of low-SES adolescents (N = 856, age = 15.98), we compared multiple well-established transdiagnostic risk factors as predictors of first incidence of significant depressive, anxiety, and substance abuse symptoms across the transition from adolescence to adulthood. Risk factors included negative emotionality, emotion regulation ability, social support, gender, history of trauma, parental histories of substance abuse, parental mental health, and socioeconomic status. Machine learning models revealed that negative emotionality was the most important predictor of both depression and anxiety, and emotion regulation ability was the most important predictor of future significant substance abuse. These findings highlight the critical role that dysregulated emotion may play in the development of some of the most prevalent forms of mental illness.

Indexed as

AnxietyDepressionEmotional RegulationJuvenile DelinquencySubstance-Related DisordersAdolescentAdultFemaleHumansLongitudinal StudiesMaleRisk FactorsSocial SupportYoung AdultAnxietyDepressionFirst incidenceMachine learningNegative emotionalityRisk factorSubstance abuseTransdiagnostic

Identifiers

PMID38782806
PMCPMC11584340

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.