Evidence map›Paper›PMID 38782589›Full record

ArticleAJNR. American journal of neuroradiology2024

Differentiating Low-Grade from High-Grade Intracranial Ependymomas: Comparison of Dynamic Contrast-Enhanced MRI and Diffusion-Weighted Imaging.

Julio Arevalo-Perez, Elena Yllera-Contreras, Kyung K Peck, Vaios Hatzoglou, Onur Yildirim, Marc K Rosenblum, Andrei I Holodny

Abstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in AJNR. American journal of neuroradiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Julio Arevalo-PerezFrom the Department of Radiology (J.A.-P., E.Y.-C., V.H., O.Y., A.I.H.), Memorial Sloan Kettering Cancer Center, New York, New York arevalj1@mskcc.org.ORCID 0000-0002-6283-0558
Elena Yllera-ContrerasFrom the Department of Radiology (J.A.-P., E.Y.-C., V.H., O.Y., A.I.H.), Memorial Sloan Kettering Cancer Center, New York, New York.ORCID 0000-0003-0666-4468
Kyung K PeckDepartment of Medical Physics (K.K.P.), Memorial Sloan Kettering Cancer Center, New York, New York.ORCID 0000-0002-9841-3078
Vaios HatzoglouFrom the Department of Radiology (J.A.-P., E.Y.-C., V.H., O.Y., A.I.H.), Memorial Sloan Kettering Cancer Center, New York, New York.
Onur YildirimFrom the Department of Radiology (J.A.-P., E.Y.-C., V.H., O.Y., A.I.H.), Memorial Sloan Kettering Cancer Center, New York, New York.ORCID 0000-0002-1586-1933
Marc K RosenblumDepartment of Pathology (M.K.R.), Memorial Sloan Kettering Cancer Center, New York, New York.
Andrei I HolodnyFrom the Department of Radiology (J.A.-P., E.Y.-C., V.H., O.Y., A.I.H.), Memorial Sloan Kettering Cancer Center, New York, New York.ORCID 0000-0002-1159-2705

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Hongbiao Carl Lekaye · 1985 to 2026
$347.4M
NCI NIH HHS P30 CA008748
6 · The paper itself

Abstract

background and purposeThe aim of this study was to determine the diagnostic value of fractional plasma volume derived from dynamic contrast-enhanced perfusion MR imaging versus ADC, obtained from DWI in differentiating between grade 2 (low-grade) and grade 3 (high-grade) intracranial ependymomas. MATERIALS AND

methodsA hospital database was created for the period from January 2013 through June 2022, including patients with histologically-proved ependymoma diagnosis with available dynamic contrast-enhanced MR imaging. Both dynamic contrast-enhanced perfusion and DWI were performed on each patient using 1.5T and 3T scanners. Fractional plasma volume maps and ADC maps were calculated. ROIs were defined by a senior neuroradiologist manually by including the enhancing tumor on every section and conforming a VOI to obtain the maximum value of fractional plasma volume (Vp

resultsA total of 20 patients with ependymomas (10 grade 2 tumors and 10 grade 3 tumors) were included. Vp

conclusionsAs a dynamic contrast-enhanced perfusion MR imaging metric, fractional plasma volume can be used as an indicator to differentiate grade 2 and grade 3 ependymomas. Dynamic contrast-enhanced perfusion MR imaging plays an important role with high diagnostic value in differentiating low- and high-grade ependymoma.

Indexed as

Brain NeoplasmsContrast MediaDiffusion Magnetic Resonance ImagingEpendymomaNeoplasm GradingAdolescentAdultAgedChildDiagnosis, DifferentialFemaleHumansMagnetic Resonance ImagingMaleMiddle AgedRetrospective StudiesContrast Media

Identifiers

PMID38782589
PMCPMC11286012

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.