ArticleJournal of nuclear medicine : official publication, Society of Nuclear Medicine2024
Patterns of Early Neocortical Amyloid-β Accumulation: A PET Population-Based Study.
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Article in Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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14citing papers in PubMed
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Who cites it
14 citing papers in PubMed.
- Characterisation of Posterior Predominant Amyloid PET Binding Across Multiple Cohorts.bioRxiv : the preprint server for biology · 2026Article
- Amyloid and tau pathologies are drivers of white matter damage in aging and Alzheimer's disease.GeroScience · 2026Article
- A unified model for staging amyloid and tau pathology in Alzheimer's disease.medRxiv : the preprint server for health sciences · 2026Article
- In vivo mapping of cortical amyloid beta-myelin coupling in preclinical Alzheimer's disease.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Association of type 2 diabetes treatment status with in vivo biomarkers of Alzheimer's disease.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Neuroimaging Epicenters as Vulnerable Nodes in Plasma p-tau217/Aβ42-Positive Alzheimer's Disease.Research (Washington, D.C.) · 2026Article
- Mechanistic modeling of amyloid dynamics relating to Alzheimer's disease progression.Frontiers in aging neuroscience · 2026Article
- Coordinated regional association of cathepsins and dipeptidyl peptidases with N-truncated Abeta42, Abeta40, and tau in Alzheimer's brain.Acta neuropathologica communications · 2025Article
- Amyloid and tau pathologies are drivers of white matter damage in aging and Alzheimer's disease.medRxiv : the preprint server for health sciences · 2025Article
- Deciphering the three-dimensional biomolecular distribution in the Alzheimer's disease brain: A multiomic approach integrating immunohistochemistry with MALDI MS imaging.Analytica chimica acta · 2025Article
- Quantification of baseline amyloid PET in individuals with subjective cognitive decline can identify risk of amyloid accumulation and cognitive worsening: the FACEHBI study.European journal of nuclear medicine and molecular imaging · 2025Article
- Diffusion kurtosis imaging detects cortical microstructural alterations in amyloid-positive MCI patients.Frontiers in dementia · 2025Article
- Amyloid PET detects the deposition of brain Aβ earlier than CSF fluid biomarkers.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024Article
- A Comparative Analysis of Two Automated Quantification Methods for Regional Cerebral Amyloid Retention: PET-Only and PET-and-MRI-Based Methods.International journal of molecular sciences · 2024Article
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Authors and funding
18 authors.
Emily E LecyDepartment of Radiology, Mayo Clinic, Rochester, Minnesota.
Hoon-Ki MinDepartment of Radiology, Mayo Clinic, Rochester, Minnesota.
Christopher J ApgarDepartment of Radiology, Mayo Clinic, Rochester, Minnesota.
Daniela D MaltaisDepartment of Radiology, Mayo Clinic, Rochester, Minnesota.
Emily S LundtDivision of Biostatistics, Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota.
Sabrina M AlbertsonDivision of Biostatistics, Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota.
Matthew L SenjemDepartment of Technology, Mayo Clinic, Rochester, Minnesota.
Christopher G SchwarzDepartment of Radiology, Mayo Clinic, Rochester, Minnesota.
Hugo BothaDepartment of Neurology, Mayo Clinic, Rochester, Minnesota; and.
Jonathan Graff-RadfordDepartment of Neurology, Mayo Clinic, Rochester, Minnesota; and.
David T JonesDepartment of Neurology, Mayo Clinic, Rochester, Minnesota; and.
Prashanthi VemuriDepartment of Radiology, Mayo Clinic, Rochester, Minnesota.
Kejal KantarciDepartment of Radiology, Mayo Clinic, Rochester, Minnesota.
David S KnopmanDepartment of Neurology, Mayo Clinic, Rochester, Minnesota; and.
Ronald C PetersenDepartment of Neurology, Mayo Clinic, Rochester, Minnesota; and.
Clifford R JackDepartment of Radiology, Mayo Clinic, Rochester, Minnesota.
Jeyeon LeeDepartment of Radiology, Mayo Clinic, Rochester, Minnesota; vlowe@mayo.edu jeyeonlee@hanyang.ac.kr.
Val J LoweDepartment of Radiology, Mayo Clinic, Rochester, Minnesota; vlowe@mayo.edu jeyeonlee@hanyang.ac.kr.
Funding
SUPPLEMENT TO ALZHEIMERS DISEASE PATIENT REGISTRYU01AG006786 · NIA · MAYO CLINIC ROCHESTER · PI GRAFF-RADFORD, JONATHAN, JACK, CLIFFORD R. · 1986 to 2023
$49.6MTHE PGRN/TDP-43 AXIS IN ALZHEIMER?S DISEASE AND NEURODEGENERATIONP50AG016574 · NIA · MAYO CLINIC ROCHESTER · PI BU, GUOJUN · 1999 to 2018
$36.9MResearch Education ComponentP30AG062677 · NIA · MAYO CLINIC ROCHESTER · PI Walter K. Kremers · 2019 to 2026
$33.5MLongitudinal Imaging Biomarkers of Prodromal DLBU01NS100620 · NINDS · MAYO CLINIC ROCHESTER · PI Bradley F Boeve, KEJAL KANTARCI · 2017 to 2026
$19.2MPREDICTING ALZHEIMERS DISEASE WITH MAGNETIC RESONANCER01AG011378 · NIA · MAYO CLINIC ROCHESTER · PI JACK, CLIFFORD R. · 1993 to 2017
$12.1MRochester Epidemiology ProjectR01AG034676 · NIA · MAYO CLINIC ROCHESTER · PI ROCCA, WALTER A, ST SAUVER, JENNIFER LYNN · 2010 to 2019
$9.5MInvestigating Resistance and Resilience Mechanisms in Alzheimer’s DiseaseR01AG056366 · NIA · MAYO CLINIC ROCHESTER · PI PRASHANTHI VEMURI · 2017 to 2026
$7.0MValidating the New Criteria for Preclinical Alzheimer's diseaseR01AG041851 · NIA · MAYO CLINIC ROCHESTER · PI JACK, CLIFFORD R., KNOPMAN, DAVID S · 2012 to 2021
$6.3MProtecting the Confidentiality of Participants in Studies of Alzheimer's Disease and Related Dementias by Replacing Face Imagery in MRIR01AG068206 · NIA · MAYO CLINIC ROCHESTER · PI SCHWARZ, CHRISTOPHER GEORGE · 2021 to 2024
$3.2MDevelopment, Validation, and Application of an Imaging based CVD ScaleR01NS097495 · NINDS · MAYO CLINIC ROCHESTER · PI VEMURI, PRASHANTHI · 2016 to 2020
$2.9MTau PET/CT for Early Detection of Alzheimer’s Disease PathologyR01AG073282 · NIA · MAYO CLINIC ROCHESTER · PI LOWE, VAL JOHN, MURRAY, MELISSA ERIN · 2021 to 2025
$2.0MNIA NIH HHS P30 AG062677NIA NIH HHS P50 AG016574NIA NIH HHS R01 AG011378NIA NIH HHS R01 AG034676NIA NIH HHS R01 AG041851NIA NIH HHS R01 AG056366NIA NIH HHS R01 AG068206NIA NIH HHS R01 AG073282NIA NIH HHS U01 AG006786NINDS NIH HHS R01 NS097495NINDS NIH HHS U01 NS100620
Abstract
The widespread deposition of amyloid-β (Aβ) plaques in late-stage Alzheimer disease is well defined and confirmed by in vivo PET. However, there are discrepancies between which regions contribute to the earliest topographic Aβ deposition within the neocortex.
Indexed as
Alzheimer DiseaseAmyloid beta-PeptidesNeocortexPositron-Emission TomographyThiazolesAgedAged, 80 and overAniline CompoundsCross-Sectional StudiesFemaleHumansLongitudinal StudiesMaleMiddle AgedRadiopharmaceuticals2-(4'-(methylamino)phenyl)-6-hydroxybenzothiazoleAmyloid beta-PeptidesAniline CompoundsRadiopharmaceuticalsThiazolesamyloid-βearly stagePETPiBPittsburgh compound B
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.