Evidence map›Paper›PMID 38782178›Full record

ArticleExperimental eye research2024

A 3D in vitro model for assessing the influence of intraocular lens: Posterior lens capsule interactions on lens epithelial cell responses.

Samira Izuagbe, Joyita Roy, Amjad Chatila, Le Quynh Hoang, Vicki Ea, Bhavya Vaish, Cynthia M Co, Aaron Ly, Hongli Wu, Liping Tang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Experimental eye research, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Samira IzuagbeDepartment of Bioengineering, University of Texas at Arlington, Arlington, TX, 76019, USA.
Joyita RoyDepartment of Bioengineering, University of Texas at Arlington, Arlington, TX, 76019, USA.
Amjad ChatilaDepartment of Bioengineering, University of Texas at Arlington, Arlington, TX, 76019, USA.
Le Quynh HoangDepartment of Bioengineering, University of Texas at Arlington, Arlington, TX, 76019, USA.
Vicki EaDepartment of Bioengineering, University of Texas at Arlington, Arlington, TX, 76019, USA.
Bhavya VaishDepartment of Bioengineering, University of Texas at Arlington, Arlington, TX, 76019, USA.
Cynthia M CoDepartment of Bioengineering, University of Texas at Arlington, Arlington, TX, 76019, USA.
Aaron LyDepartment of Bioengineering, University of Texas at Arlington, Arlington, TX, 76019, USA.
Hongli WuDepartment of Pharmaceutical Sciences, College of Pharmacy, North Texas Eye Research Institute, University of North Texas Health Science Center, Fort Worth, TX, 76107, USA.
Liping TangDepartment of Bioengineering, University of Texas at Arlington, Arlington, TX, 76019, USA. Electronic address: ltang@uta.edu.

Funding

Mechanistic Insights and Therapeutic Potential of the Glutaredoxin (Grx) System in the LensR21EY033941 · NEI · UNIVERSITY OF NORTH TEXAS HLTH SCI CTR · PI WU, HONGLI · 2023 to 2024
$409k
NEI NIH HHS R21 EY033941
6 · The paper itself

Abstract

Posterior Capsule Opacification (PCO), the most frequent complication of cataract surgery, is caused by the infiltration and proliferation of lens epithelial cells (LECs) at the interface between the intraocular lens (IOL) and posterior lens capsule (PLC). According to the "no space, no cells, no PCO" theory, high affinity (or adhesion force) between the IOL and PLC would decrease the IOL: PLC interface space, hinder LEC migration, and thus reduce PCO formation. To test this hypothesis, an in vitro hemisphere-shaped simulated PLC (sPLC) was made to mimic the human IOL: PLC physical interactions and to assess their influence on LEC responses. Three commercially available IOLs with different affinities/adhesion forces toward the sPLC, including Acrylic foldable IOL, Silicone IOL, and PMMA IOL, were used in this investigation. Using the system, the physical interactions between IOLs and sPLC were quantified by measuring the adhesion force and interface space using an adhesion force apparatus and Optical Coherence Tomography, respectively. Our data shows that high adhesion force and tight binding between IOL and sPLC contribute to a small interface space (or "no space"). By introducing LECs into the in vitro system, we found that, with small interface space, among all IOLs, acrylic foldable IOLs permitted the least extent of LEC infiltration, proliferation, and differentiation (or "no cells"). Further statistical analyses using clinical data revealed that weak LEC responses are associated with low clinical PCO incidence rates (or "no PCO"). The findings support that the in vitro system could simulate IOL: PLC interplays and predict IOLs' PCO potential in support of the "no space, no cells, no PCO" hypothesis.

Indexed as

Capsule OpacificationEpithelial CellsLenses, IntraocularPosterior Capsule of the LensCell MovementCell ProliferationCells, CulturedHumansAdhesion forceInfiltrationIntraocular lensIn vitro modelLens epithelial cellsNo cellsNo PCO” hypothesis“No spacePCOProliferation

Identifiers

PMID38782178
PMCPMC11246700

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.