Evidence map›Paper›PMID 38781942›Full record

ArticleCerebrovascular diseases (Basel, Switzerland)2025

Changes in Migraine Symptoms after Ischemic Stroke: A Cohort Study.

Nelleke van der Weerd, Nadine Pelzer, Emma Egberts, Marit Mertens, Willemijn Bakker, Katie M Linstra, Arn M J M van den Maagdenberg, Erik W van Zwet, Antoinette MaassenVanDenBrink, Gisela M Terwindt and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cerebrovascular diseases (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Nelleke van der WeerdDepartment of Neurology, Leiden University Medical Centre, Leiden, The Netherlands.
Nadine PelzerDepartment of Neurology, Leiden University Medical Centre, Leiden, The Netherlands.
Emma EgbertsDepartment of Neurology, Leiden University Medical Centre, Leiden, The Netherlands.
Marit MertensDepartment of Neurology, Leiden University Medical Centre, Leiden, The Netherlands.
Willemijn BakkerDepartment of Neurology, Leiden University Medical Centre, Leiden, The Netherlands.
Katie M LinstraDepartment of Neurology, Leiden University Medical Centre, Leiden, The Netherlands.
Arn M J M van den MaagdenbergDepartment of Neurology, Leiden University Medical Centre, Leiden, The Netherlands.
Erik W van ZwetDepartment of Medical Statistics, Leiden University Medical Centre, Leiden, The Netherlands.
Antoinette MaassenVanDenBrinkDepartment of Internal Medicine, Erasmus University Medical Centre, Rotterdam, The Netherlands.
Gisela M TerwindtDepartment of Neurology, Leiden University Medical Centre, Leiden, The Netherlands.
Marieke J H WermerDepartment of Neurology, Leiden University Medical Centre, Leiden, The Netherlands.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionMigraine symptoms are postulated to improve post-stroke. We aimed to determine post-stroke changes in patients with active migraine pre-stroke and explored the relation with stroke location and stroke-preventive medication use.

methodsPatients with active migraine who had an ischemic stroke were retrieved from three research-cohorts between 2014 and 2021. By an interview, we retrospectively investigated first-year post-stroke changes for those ischemic stroke patients that suffered from migraine pre-stroke. Associations between change in migraine frequency/intensity/aura (decrease, no change, increase), stroke location (posterior location vs. other), and use of secondary stroke preventive medication were assessed by ordinal regression with adjustment for confounders.

resultsWe included 78 patients (mean age 48 years, 86% women, 47% with aura). Change in migraine symptomatology was reported by 63 (81%) patients; 51 (81%) noticed a decrease in attack frequency (27 no attacks) and 12 (19%) an increase. Pain intensity change was reported by 18 (35%) patients (50% increase, 50% decrease). Aura symptomatology improved in 4 (11%). Reduced attack frequency was not related to posterior stroke (OR = 1.5, 95% CI: 0.6-3.9), or preventive medication (antiplatelets OR = 1.0, 95% CI: 0.2-3.7; coumarin OR = 2.7, 95% CI: 0.4-20.6).

conclusionsMost patients with active pre-stroke migraine experience improvement of their symptoms in the first year after ischemic stroke. This change does not seem to be related to secondary stroke preventive medication or posterior stroke location.

Indexed as

Ischemic StrokeMigraine DisordersMigraine with AuraAdultAgedFemaleHumansMaleMiddle AgedPlatelet Aggregation InhibitorsRetrospective StudiesRisk FactorsSecondary PreventionTime FactorsPlatelet Aggregation InhibitorsCerebral vasculatureComorbidityIschemic strokeMigrainePost-stroke

Identifiers

PMID38781942
PMCPMC12136600

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.