ArticleEmerging infectious diseases2024
Chest Radiograph Screening for Detecting Subclinical Tuberculosis in Asymptomatic Household Contacts, Peru.
Article in Emerging infectious diseases, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- Risk of progression to pulmonary tuberculosis among household contacts with chest radiographic abnormalities in South Africa.medRxiv : the preprint server for health sciences · 2026Article
- A public-private partnership for facility-based tuberculosis screening using chest radiographs, Viet Nam.Bulletin of the World Health Organization · 2026Article
- A two-step hybridization-capture aptasensor with dithiol-DNA-AuNPs interface for rapid, label-free detection of Mycobacterium tuberculosis H37Rv.Analytical and bioanalytical chemistry · 2026Article
- The hidden burden: a regional study revealing the substantial burden and distinct epidemiology of asymptomatic pulmonary tuberculosis in Southern China.BMC public health · 2026Article
- Reappraising TB preventive treatment in India: programmatic and ethical implications of subclinical tuberculosis in household contacts.The Lancet regional health. Southeast Asia · 2026Review
- TB-Free Chuuk: community-wide tuberculosis prevention and treatment with an integrated disease screening approach in Chuuk Lagoon, Federated States of Micronesia.BMJ public health · 2026Article
- Evaluation of the performance of promising host transcriptional biosignatures in predicting TB progression during a 1-year prospective cohort study in Indian household contacts.Frontiers in tuberculosis · 2026Article
- ddPCR-based profiling of plasma EV-miRNA identifies a noninvasive biomarker panel for tuberculosis.European journal of medical research · 2025Article
- Evaluation of an ultra-portable X-ray system with automated interpretation for tuberculosis active case finding in carceral settings: a diagnostic test accuracy study.BMC infectious diseases · 2025Article
- Integrating Early Tuberculosis States Into Contact Management in Peru.JAMA network open · 2025Article
- Evaluation of an ultra-portable X-ray system with automated interpretation for tuberculosis active case finding in carceral settings: a diagnostic test accuracy study.Research square · 2025Article
- Unrecognized Tuberculosis: Risk Factors for Smear-Positive/Cavitary Asymptomatic Cases.Open forum infectious diseases · 2025Article
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Authors and funding
15 authors.
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Abstract
The World Health Organization's end TB strategy promotes the use of symptom and chest radiograph screening for tuberculosis (TB) disease. However, asymptomatic early states of TB beyond latent TB infection and active disease can go unrecognized using current screening criteria. We conducted a longitudinal cohort study enrolling household contacts initially free of TB disease and followed them for the occurrence of incident TB over 1 year. Among 1,747 screened contacts, 27 (52%) of the 52 persons in whom TB subsequently developed during follow-up had a baseline abnormal radiograph. Of contacts without TB symptoms, persons with an abnormal radiograph were at higher risk for subsequent TB than persons with an unremarkable radiograph (adjusted hazard ratio 15.62 [95% CI 7.74-31.54]). In young adults, we found a strong linear relationship between radiograph severity and time to TB diagnosis. Our findings suggest chest radiograph screening can extend to detecting early TB states, thereby enabling timely intervention.
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