ArticleScience (New York, N.Y.)2024
Reversible male contraception by targeted inhibition of serine/threonine kinase 33.
Abstract read
In one paragraph
Article in Science (New York, N.Y.), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
–field-weighted citation impact
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed.
- A small molecule inhibits Ebola virus entry through glycoprotein stabilization.Nature communications · 2026Article
- Identification of potent inhibitors of JUN N-terminal kinases for treatment of endometriosis and associated pain.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Automated DNA-Encoded Library Synthesis and Activity-Based Screening at the Attomole Scale.Journal of medicinal chemistry · 2026Article
- Molecular interplay between sperm and oocyte: a narrative review.Human reproduction update · 2026Review
- Small-molecule modulators of HIPK4 activity and proteostasis.bioRxiv : the preprint server for biology · 2026Article
- Advances in BRET probes for intracellular target engagement studies.Nature chemical biology · 2026Review
- An extracellular vesicle-mediated mitochondrial transfer network critical for testosterone synthesis.Nature cell biology · 2026Article
- From Discovery to Clinical Trial: YCT-529, an Oral NonHormonal Male Contraceptive Targeting the Retinoic Acid Receptor Alpha.Journal of medicinal chemistry · 2026Article
- Article
- The kinesin-4 protein KIF27 forms a cytoskeletal scaffold at the transition zone to promote motile cilia structural integrity.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Discovery of a novel small molecule degrader of wild type and mutant estrogen receptors using DNA encoded libraries.NPJ breast cancer · 2025Article
- Stage-Resolved Phosphoproteomic Landscape of Mouse Spermiogenesis Reveals Key Kinase Signaling in Sperm Morphogenesis.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Inhibition of ROS1 activity with lorlatinib reversibly suppresses fertility in male mice.Andrology · 2025Article
- Short peptide perturbs spermatogenesis via immune microenvironment dysregulation and mitochondrial imbalance.FEBS open bio · 2025Article
- Evaluation of Ambient Ozone Pollution Exposure on Mice Testicular Tissue: An Integrated Metabolomic and Transcriptomic Analysis.Reproductive sciences (Thousand Oaks, Calif.) · 2025Article
- PSA inhibitors for contraception: insights from prostate cancer.Trends in pharmacological sciences · 2025Review
- STK33 as the functional substrate of miR-454-3p for suppression and apoptosis in neuroblastoma.Molecules and cells · 2024Article
- Discovery of highly potent and ALK2/ALK1 selective kinase inhibitors using DNA-encoded chemistry technology.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Novel Genes of the Male Reproductive System: Potential Roles in Male Reproduction and as Non-hormonal Male Contraceptive Targets.Molecular reproduction and development · 2024Review
Corrections and comments
- Commented on by
Authors and funding
30 authors.
Angela F KuCenter for Drug Discovery, Department of Pathology & Immunology, Baylor College of Medicine, Houston, TX 77030, USA.ORCID 0000-0003-1768-9345
Kiran L Sharma *Center for Drug Discovery, Department of Pathology & Immunology, Baylor College of Medicine, Houston, TX 77030, USA.ORCID 0000-0002-1988-389X
Hai Minh Ta *Center for Drug Discovery, Department of Pathology & Immunology, Baylor College of Medicine, Houston, TX 77030, USA.ORCID 0000-0002-7298-6177
Courtney M Sutton *Center for Drug Discovery, Department of Pathology & Immunology, Baylor College of Medicine, Houston, TX 77030, USA.ORCID 0000-0001-9994-990X
Kurt M BohrenCenter for Drug Discovery, Department of Pathology & Immunology, Baylor College of Medicine, Houston, TX 77030, USA.ORCID 0000-0002-3183-4118
Yong WangCenter for Drug Discovery, Department of Pathology & Immunology, Baylor College of Medicine, Houston, TX 77030, USA.
Srinivas ChamakuriCenter for Drug Discovery, Department of Pathology & Immunology, Baylor College of Medicine, Houston, TX 77030, USA.ORCID 0000-0002-7586-4992
Ruihong ChenCenter for Drug Discovery, Department of Pathology & Immunology, Baylor College of Medicine, Houston, TX 77030, USA.
John M HakenjosCenter for Drug Discovery, Department of Pathology & Immunology, Baylor College of Medicine, Houston, TX 77030, USA.ORCID 0009-0008-4047-6923
Ravikumar JimmidiCenter for Drug Discovery, Department of Pathology & Immunology, Baylor College of Medicine, Houston, TX 77030, USA.ORCID 0000-0003-3819-0092
Katarzyna KentCenter for Drug Discovery, Department of Pathology & Immunology, Baylor College of Medicine, Houston, TX 77030, USA.ORCID 0000-0002-4528-3425
Feng LiCenter for Drug Discovery, Department of Pathology & Immunology, Baylor College of Medicine, Houston, TX 77030, USA.ORCID 0000-0002-9680-4614
Jian-Yuan LiCenter for Drug Discovery, Department of Pathology & Immunology, Baylor College of Medicine, Houston, TX 77030, USA.ORCID 0000-0003-4733-1010
Lang MaCenter for Drug Discovery, Department of Pathology & Immunology, Baylor College of Medicine, Houston, TX 77030, USA.
Chandrashekhar MadasuCenter for Drug Discovery, Department of Pathology & Immunology, Baylor College of Medicine, Houston, TX 77030, USA.ORCID 0000-0002-2152-9689
Murugesan PalaniappanCenter for Drug Discovery, Department of Pathology & Immunology, Baylor College of Medicine, Houston, TX 77030, USA.ORCID 0000-0003-4916-6565
Stephen S PalmerCenter for Drug Discovery, Department of Pathology & Immunology, Baylor College of Medicine, Houston, TX 77030, USA.
Xuan QinCenter for Drug Discovery, Department of Pathology & Immunology, Baylor College of Medicine, Houston, TX 77030, USA.ORCID 0000-0003-3728-5911
Matthew B RobersPromega Corporation, Madison, WI 53711, USA.
Banumathi SankaranMolecular Biophysics and Integrated Bioimaging, Berkeley Center for Structural Biology, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA.ORCID 0000-0002-3266-8131
Zhi TanCenter for Drug Discovery, Department of Pathology & Immunology, Baylor College of Medicine, Houston, TX 77030, USA.
Yasmin M VasquezCenter for Drug Discovery, Department of Pathology & Immunology, Baylor College of Medicine, Houston, TX 77030, USA.ORCID 0000-0003-4255-9761
Jian WangCenter for Drug Discovery, Department of Pathology & Immunology, Baylor College of Medicine, Houston, TX 77030, USA.ORCID 0009-0000-9178-1225
Jennifer WilkinsonPromega Corporation, Madison, WI 53711, USA.ORCID 0009-0002-1994-715X
Zhifeng YuCenter for Drug Discovery, Department of Pathology & Immunology, Baylor College of Medicine, Houston, TX 77030, USA.ORCID 0000-0002-3130-6438
Qiuji YeCenter for Drug Discovery, Department of Pathology & Immunology, Baylor College of Medicine, Houston, TX 77030, USA.ORCID 0000-0002-3812-3001
Damian W YoungCenter for Drug Discovery, Department of Pathology & Immunology, Baylor College of Medicine, Houston, TX 77030, USA.
Mingxing TengCenter for Drug Discovery, Department of Pathology & Immunology, Baylor College of Medicine, Houston, TX 77030, USA.ORCID 0000-0001-6574-1764
Choel KimCenter for Drug Discovery, Department of Pathology & Immunology, Baylor College of Medicine, Houston, TX 77030, USA.ORCID 0000-0002-3152-0020
Martin M MatzukCenter for Drug Discovery, Department of Pathology & Immunology, Baylor College of Medicine, Houston, TX 77030, USA.ORCID 0000-0002-1445-8632
Funding
User Training and OutreachP30GM124169 · NIGMS · UNIVERSITY OF CALIF-LAWRENC BERKELEY LAB · PI Gregory L Hura · 2017 to 2026
$28.6MGenetics & Genomics Training ProgramT32GM139534 · NIGMS · BAYLOR COLLEGE OF MEDICINE · PI GAD SHAULSKY · 2021 to 2026
$4.8MFunctional analysis of novel testis-expressed secreted and transmembrane proteinsR01HD088412 · NICHD · BAYLOR COLLEGE OF MEDICINE · PI MARTIN M. MATZUK · 2016 to 2026
$4.5MElucidating Chemical Features that Block or Facilitate Passage across the Blood-Testis and/or Blood-Epidydimal Barriers in MiceR33HD099995 · NICHD · BAYLOR COLLEGE OF MEDICINE · PI LI, FENG · 2022 to 2024
$1.7MDevelopment of a Precision Drug to target Y537S Mutant Estrogen Receptor in Metastatic Breast CancerR03CA259664 · NCI · BAYLOR COLLEGE OF MEDICINE · PI PALANIAPPAN, MURUGESAN · 2022 to 2023
$160kProtein Crystallization ImagerS10OD030246 · OD · BAYLOR COLLEGE OF MEDICINE · PI LEE, SUKYEONG · 2021 to 2021
$136kGates Foundation INV-001902NCI NIH HHS R03 CA259664NICHD NIH HHS R01 HD088412NICHD NIH HHS R33 HD099995NIGMS NIH HHS P30 GM124169NIGMS NIH HHS T32 GM139534NIH HHS S10 OD030246
Abstract
Men or mice with homozygous serine/threonine kinase 33 (
Indexed as
ContraceptionContraceptive Agents, MaleProtein Kinase InhibitorsProtein Serine-Threonine KinasesSmall Molecule LibrariesAnimalsBlood-Testis BarrierHumansMaleMiceStructure-Activity RelationshipTestisContraceptive Agents, MaleProtein Kinase InhibitorsProtein Serine-Threonine KinasesSmall Molecule LibrariesSTK33 protein, humanStk33 protein, mouse
Identifiers
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LicenceCC BY
Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.