ArticlePloS one2024
Cerebral cortex activation and functional connectivity during low-load resistance training with blood flow restriction: An fNIRS study.
Article in PloS one, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.
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Who cites it
10 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Impact of low-load blood flow restriction training on knee osteoarthritis pain and muscle strength: a systematic review and meta-analysis of randomized controlled trials.Frontiers in physiology · 2025Pooled it
- Trial
- Acute hemoglobin responses during bench press exercise across relative loads and sport backgrounds: a cross-sectional functional near-infrared spectroscopy study.European journal of applied physiology · 2026Article
- Translational perspectives on neurophysiological responses and mechanisms in blood flow restriction exercise.Experimental physiology · 2026Review
- Acute effects of upper-limb blood flow restriction training on dual-task postural control and physiological correlates in older adults.Journal of neuroengineering and rehabilitation · 2026Article
- Answer to the Letter to the Editor of D. Yuan, et al. concerning "Evaluation of blood flow restriction combined with routine rehabilitation in incomplete thoracic and lumbar spinal cord injury after decompression: a retrospective study" by G. Xiao, et al. (Eur Spine J [2025]; doi: 10.1007/s00586-025-09412-9).European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2026Article
- Blood flow responses to different set pressures using elastic "multichambered" blood flow restriction bands.Frontiers in sports and active living · 2026Article
- Unpacking the blood flow restriction device features literature: multi-chambered bladder design.Frontiers in sports and active living · 2024Article
- Why blood flow restriction cuff features are an important methodological consideration- a short commentary on "cerebral cortex activation and functional connectivity during low-load resistance training with blood flow restriction: an fNIRS study".Frontiers in physiology · 2024Article
- Effects of blood flow restriction combined with robot-assisted training on upper limb motor function after stroke: a randomized controlled trial protocol.Frontiers in neurologyArticle
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Authors and funding
4 authors.
Funding
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Abstract
Despite accumulating evidence that blood flow restriction (BFR) training promotes muscle hypertrophy and strength gain, the underlying neurophysiological mechanisms have rarely been explored. The primary goal of this study is to investigate characteristics of cerebral cortex activity during BFR training under different pressure intensities. 24 males participated in 30% 1RM squat exercise, changes in oxygenated hemoglobin concentration (HbO) in the primary motor cortex (M1), pre-motor cortex (PMC), supplementary motor area (SMA), and dorsolateral prefrontal cortex (DLPFC), were measured by fNIRS. The results showed that HbO increased from 0 mmHg (non-BFR) to 250 mmHg but dropped sharply under 350 mmHg pressure intensity. In addition, HbO and functional connectivity were higher in M1 and PMC-SMA than in DLPFC. Moreover, the significant interaction effect between pressure intensity and ROI for HbO revealed that the regulation of cerebral cortex during BFR training was more pronounced in M1 and PMC-SMA than in DLPFC. In conclusion, low-load resistance training with BFR triggers acute responses in the cerebral cortex, and moderate pressure intensity achieves optimal neural benefits in enhancing cortical activation. M1 and PMC-SMA play crucial roles during BFR training through activation and functional connectivity regulation.
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