ArticleProceedings of the National Academy of Sciences of the United States of America2024
IL-33 controls IL-22-dependent antibacterial defense by modulating the microbiota.
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Article in Proceedings of the National Academy of Sciences of the United States of America, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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8citing papers in PubMed
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Who cites it
8 citing papers in PubMed.
- Blockade of Interleukin-6 Trans-signaling in the Presence of Certain Gut Microbiota Induces Mature-onset Obesity in Mice.Gastro hep advances · 2026Article
- Gut microbiota dysbiosis in infants and young children with severe pneumonia and sepsis: a matched case-control study identifying potential biomarkers for early risk stratification.Frontiers in immunology · 2026Article
- Exosomes from adipose-derived stem cells accelerate wound healing by increasing the release of IL-33 from macrophages.Stem cell research & therapy · 2025Article
- IL-33 Induces a Switch in Intestinal Metabolites Revealing the Tryptophan Pathway as a Target for Inducing Allograft Survival.Nutrients · 2024Article
- Intestinal Microbiota and Its Effect on Vaccine-Induced Immune Amplification and Tolerance.Vaccines · 2024Review
- Gut microbes coordinate pulmonary immunity.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- IL-33 controls IL-22-dependent antibacterial defense by modulating the microbiota.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
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Authors and funding
25 authors.
Ivo Röwekamp *Department of Infectious Diseases, Respiratory Medicine and Critical Care, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin 13353, Germany.
Laura Maschirow *Department of Infectious Diseases, Respiratory Medicine and Critical Care, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin 13353, Germany.ORCID 0000-0002-7727-2544
Anne Rabes *Department of Infectious Diseases, Respiratory Medicine and Critical Care, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin 13353, Germany.
Facundo Fiocca VernengoDepartment of Infectious Diseases, Respiratory Medicine and Critical Care, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin 13353, Germany.
Lutz HamannInstitute of Microbiology, Infectious Diseases and Immunology, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin 12203, Germany.ORCID 0000-0003-4719-2583
Gitta Anne HeinzGerman Rheumatism Research Center, a Leibniz Institute, Berlin 10117, Germany.ORCID 0000-0002-9330-3689
Mir-Farzin MashreghiGerman Rheumatism Research Center, a Leibniz Institute, Berlin 10117, Germany.ORCID 0000-0002-8015-6907
Sandra CaesarDepartment of Infectious Diseases, Respiratory Medicine and Critical Care, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin 13353, Germany.
Miha MilekCore Unit Bioinformatics, Berlin Institute of Health at Charité, Berlin 10117, Germany.ORCID 0000-0002-0803-8439
Anna Carolina Fagundes FonsecaInstitute of Microbiology, Infectious Diseases and Immunology, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin 12203, Germany.ORCID 0009-0003-9027-8136
Sandra-Maria WienholdDepartment of Infectious Diseases, Respiratory Medicine and Critical Care, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin 13353, Germany.
Geraldine NouaillesDepartment of Infectious Diseases, Respiratory Medicine and Critical Care, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin 13353, Germany.ORCID 0000-0003-1973-3119
Ling YaoDepartment of Infectious Diseases, Respiratory Medicine and Critical Care, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin 13353, Germany.ORCID 0000-0002-0482-9604
Soraya MousaviInstitute of Microbiology, Infectious Diseases and Immunology, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin 12203, Germany.
Dunja BruderResearch Group Infection Immunology, Institute of Medical Microbiology and Hospital Hygiene, Health Campus Immunology, Infectiology and Inflammation, Otto-von-Guericke-University, Magdeburg 39120, Germany.ORCID 0000-0003-3066-189X
Julia D BoehmeResearch Group Infection Immunology, Institute of Medical Microbiology and Hospital Hygiene, Health Campus Immunology, Infectiology and Inflammation, Otto-von-Guericke-University, Magdeburg 39120, Germany.ORCID 0000-0002-6257-0952
Monika Puzianowska-KuznickaDepartment of Human Epigenetics, Mossakowski Medical Research Institute, Polish Academy of Sciences, Warsaw 02-106, Poland.ORCID 0000-0001-5295-3848
Dieter BeuleCore Unit Bioinformatics, Berlin Institute of Health at Charité, Berlin 10117, Germany.
Martin WitzenrathDepartment of Infectious Diseases, Respiratory Medicine and Critical Care, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin 13353, Germany.
CAPNETZ Study Group
Max LöhningExperimental Immunology and Osteoarthritis Research, Department of Rheumatology and Clinical Immunology, Charité-Universitätsmedizin Berlin, Corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin 10117, Germany.ORCID 0000-0001-6382-7281
Christoph S N KloseInstitute of Microbiology, Infectious Diseases and Immunology, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin 12203, Germany.ORCID 0000-0001-8803-2979
Markus M HeimesaatInstitute of Microbiology, Infectious Diseases and Immunology, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin 12203, Germany.ORCID 0000-0001-6399-651X
Andreas DiefenbachInstitute of Microbiology, Infectious Diseases and Immunology, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin 12203, Germany.ORCID 0000-0002-9176-9530
Bastian OpitzDepartment of Infectious Diseases, Respiratory Medicine and Critical Care, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin 13353, Germany.ORCID 0000-0003-1276-836X
Funding
Bundesministerium für Bildung und Forschung (BMBF) MAPVAP FKZ 01KI2124Deutsche Forschungsgemeinschaft (DFG) FOR2599 - 322359157Deutsche Forschungsgemeinschaft (DFG) OP86/13-1Deutsche Forschungsgemeinschaft (DFG) SFB1444 TP11Deutsche Forschungsgemeinschaft (DFG) SFB-TR84 A1Deutsche Forschungsgemeinschaft (DFG) SPP1937 - KL 2963/2-1 and KL 2963/3-1Deutsche Forschungsgemeinschaft (DFG) TRR 167 - 259373024Deutsche Forschungsgemeinschaft (DFG) TRR 241 - 375876048EC | ERC | HORIZON EUROPE European Research Council (ERC) Advanced Grant 101055309 - ILCADAPTEC | ERC | HORIZON EUROPE European Research Council (ERC) ERCEA; 803087Einstein Foundation Berlin Einstein Professor
Abstract
IL-22 plays a critical role in defending against mucosal infections, but how IL-22 production is regulated is incompletely understood. Here, we show that mice lacking IL-33 or its receptor ST2 (IL-1RL1) were more resistant to
Indexed as
Immunity, InnateInterleukin-1 Receptor-Like 1 ProteinInterleukin-22Interleukin-33InterleukinsStreptococcus pneumoniaeAnimalsGastrointestinal MicrobiomeHumansLymphocytesMiceMice, Inbred C57BLMice, KnockoutMicrobiotaPneumonia, PneumococcalPolymorphism, Single NucleotideIl1rl1 protein, mouseIl33 protein, mouseInterleukin-1 Receptor-Like 1 ProteinInterleukin-22Interleukin-33InterleukinsIL-22IL-33microbiotapneumoniaStreptococcus pneumoniae
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LicenceCC BY-NC-ND
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.