Evidence map›Paper›PMID 38781101›Full record

ArticleNano letters2024

In-Brain Multiphoton Imaging of Vaterite Cargoes Loaded with Carbon Dots.

Hani Barhum, Cormac McDonnell, Oleksii Peltek, Rudhvi Jain, Mariam Amer, David Kain, Galit Elad-Sfadia, Muhammad Athamna, Pablo Blinder, Pavel Ginzburg

Abstract read
In one paragraph

Article in Nano letters, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Hani BarhumDepartment of Electrical Engineering, Tel Aviv University, Ramat Aviv, Tel Aviv 69978, Israel.ORCID 0000-0003-0214-0288
Cormac McDonnellDepartment of Electrical Engineering, Tel Aviv University, Ramat Aviv, Tel Aviv 69978, Israel.ORCID 0000-0003-1251-9339
Oleksii PeltekSchool of Physics and Engineering, ITMO University, St. Petersburg 191002, Russian Federation.
Rudhvi JainNeurobiology, Biochemistry and Biophysics School, Wise Life Science Faculty, Tel Aviv University, Tel Aviv 69978, Israel.
Mariam AmerTriangle Regional Research and Development Center, Kfar Qara 3007500, Israel.
David KainSagol School of Neuroscience, Tel Aviv University, Tel Aviv 69978, Israel.
Galit Elad-SfadiaNeurobiology, Biochemistry and Biophysics School, Wise Life Science Faculty, Tel Aviv University, Tel Aviv 69978, Israel.
Muhammad AthamnaTriangle Regional Research and Development Center, Kfar Qara 3007500, Israel.
Pablo BlinderNeurobiology, Biochemistry and Biophysics School, Wise Life Science Faculty, Tel Aviv University, Tel Aviv 69978, Israel.
Pavel GinzburgDepartment of Electrical Engineering, Tel Aviv University, Ramat Aviv, Tel Aviv 69978, Israel.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Biocompatible fluorescent agents are key contributors to the theranostic paradigm by enabling real-time in vivo imaging. This study explores the optical properties of phenylenediamine carbon dots (CDs) and demonstrates their potential for fluorescence imaging in cells and brain blood vessels. The nonlinear absorption cross-section of the CDs was measured and achieved values near 50 Goeppert-Mayer (GM) units with efficient excitation in the 775-895 nm spectral range. Mesoporous vaterite nanoparticles were loaded with CDs to examine the possibility of a biocompatible imaging platform. Efficient one- and two-photon imaging of the CD-vaterite composites uptaken by diverse cells was demonstrated. For an in vivo scenario, CD-vaterite composites were injected into the bloodstream of a mouse, and their flow was monitored within the blood vessels of the brain through a cranial window. These results show the potential of the platform for high-brightness biocompatible imaging with the potential for both sensing and simultaneous drug delivery.

Indexed as

BrainCarbonQuantum DotsAnimalsCalcium CarbonateFluorescent DyesHumansMiceMicroscopy, Fluorescence, MultiphotonNanoparticlesCalcium CarbonateCarbonFluorescent DyesBioimagingCarbon DotsCross-sectionPhenylenediamineTwo-photon fluorescence (2PF)Vaterite

Identifiers

PMID38781101
PMCPMC11247546

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.