ArticleCell reports2024
Protective role for kidney TREM2
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Article in Cell reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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28citing papers in PubMed
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Who cites it
28 citing papers in PubMed.
- Endothelial dysfunction in human diabetic vascular complications: translating single-cell transcriptomics into therapeutic opportunities.Molecular medicine (Cambridge, Mass.) · 2026Review
- Kidney-Vascular Metabolic Crosstalk: Altered Lipoproteins in CKD.Circulation research · 2026Review
- Apolipoprotein E knockout attenuates vascular graft fibrosis by reducing profibrotic macrophage formation through low-density lipoprotein receptor related protein 1.Bioactive materials · 2026Article
- Diabetes-induced TREM2-endothelial cell signaling impairs ischemic vascular repair.Science translational medicine · 2026Article
- A population-scale atlas of blood and tissue in lupus nephritis.bioRxiv : the preprint server for biology · 2026Article
- Obesity and Its Clinical Implications in End-Stage Kidney Disease.Medicina (Kaunas, Lithuania) · 2026Review
- Macrophage polarization in ischemia-reperfusion injury: from molecular mechanisms to therapeutic strategies.Frontiers in immunology · 2026Review
- Immune Cell Infiltration and Kynurenine Pathway Activation Define Early Injury and Progression in Diabetic Nephropathy.International journal of biological sciences · 2026Article
- TREM2: A Potential Target for the Targeted Therapy of Metabolic Diseases.Mediators of inflammation · 2026Review
- Trem2 activation by renal tubular debris sustains Arg1Frontiers in immunology · 2026Article
- Macrophage Trem2 deficiency aggravates aging-induced vascular remodeling by acting as a non-classical receptor of interleukin-13.Molecular biomedicine · 2025Article
- TREM2-driven peripheral macrophage regulation in inflammatory diseases: implications extending beyond neurological disorders.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2025Review
- Article
- A human-mouse atlas of intrarenal myeloid cells identifies conserved disease-associated macrophages in lupus nephritis.The Journal of experimental medicine · 2025Article
- The spatial and temporal activation of macrophages during fibrosis.Nature reviews. Immunology · 2025Review
- Waist-to-height ratio and the incidence of rapid kidney function decline and chronic kidney disease: insights from the China health and retirement longitudinal study.BMC nephrology · 2025Article
- Genetic influences on macrophage function and lipid uptake in atherosclerosis.Current opinion in lipidology · 2025Review
- RasGRP4 Exacerbates Diabetic Kidney Fibrosis via Aloxe3-Mediated Oxidative Stress and Scar-Associated Macrophage Activation.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2025Article
- TREM2Experimental physiology · 2025Article
- An adoptive cell therapy with TREM2-overexpressing macrophages mitigates the transition from acute kidney injury to chronic kidney disease.Clinical and translational medicine · 2025Article
Corrections and comments
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Authors and funding
36 authors.
Ayshwarya SubramanianKlarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA, USA; Broad Institute of MIT and Harvard, Cambridge, MA, USA. Electronic address: as3894@cornell.edu.
Katherine A VernonBroad Institute of MIT and Harvard, Cambridge, MA, USA.
Yiming ZhouBroad Institute of MIT and Harvard, Cambridge, MA, USA. Electronic address: zhouym35@mail.sysu.edu.cn.
Jamie L MarshallBroad Institute of MIT and Harvard, Cambridge, MA, USA; Kidney Disease Initiative, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Maria AlimovaKidney Disease Initiative, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Carlos ArevaloBroad Institute of MIT and Harvard, Cambridge, MA, USA; Kidney Disease Initiative, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Fan ZhangDepartment of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
Michal SlyperKlarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Julia WaldmanKlarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Monica S MontesinosBroad Institute of MIT and Harvard, Cambridge, MA, USA.
Danielle DionneBroad Institute of MIT and Harvard, Cambridge, MA, USA.
Lan T NguyenBroad Institute of MIT and Harvard, Cambridge, MA, USA.
Michael S CuocoBroad Institute of MIT and Harvard, Cambridge, MA, USA.
Dan DubinskyKlarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Jason PurnellKlarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Keith KellerKidney Disease Initiative, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Samuel H SturnerBroad Institute of MIT and Harvard, Cambridge, MA, USA.
Elizabeth GrinkevichKidney Disease Initiative, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Ayan GhoshalBroad Institute of MIT and Harvard, Cambridge, MA, USA.
Amanda KotekDepartment of Pathology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
Giorgio TrivioliMolecular Immunity Unit, Department of Medicine, University of Cambridge, Cambridge, UK; Nephrology Department, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK.
Nathan RichozMolecular Immunity Unit, Department of Medicine, University of Cambridge, Cambridge, UK.
Mary B HumphreyDepartment of Internal Medicine, Division of Nephrology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA.
Isabella G DarbyDepartment of Internal Medicine, Division of Nephrology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA.
Sarah J MillerDepartment of Internal Medicine, Division of Nephrology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA.
Yingping XuInstitute of Dermatology and Venereology, Dermatology Hospital, Southern Medical University, Guangzhou, China.
Astrid WeinsDepartment of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA; Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
Alexandra Chloe-VillaniBroad Institute of MIT and Harvard, Cambridge, MA, USA.
Steven L ChangCenter for Surgery and Public Health, Brigham and Women's Hospital, Boston, MA, USA; Division of Urology, Brigham and Women's Hospital, Boston, MA, USA.
Matthias KretzlerInternal Medicine, Department of Nephrology, University of Michigan, Ann Arbor, MI, USA.
Orit Rosenblatt-RosenKlarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Jillian L ShawBroad Institute of MIT and Harvard, Cambridge, MA, USA; Kidney Disease Initiative, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Kurt A ZimmermanDepartment of Internal Medicine, Division of Nephrology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA.
Menna R ClatworthyMolecular Immunity Unit, Department of Medicine, University of Cambridge, Cambridge, UK; Cellular Genetics, Wellcome Sanger Institute, Hinxton, UK; NIHR Cambridge Biomedical Research Center, Cambridge, UK; Cambridge Institute of Therapeutic Immunology and Infectious Diseases, Cambridge, UK.
Aviv RegevKlarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA, USA; Howard Hughes Medical Institute, Department of Biology, Massachusetts Institute of Technology, Cambridge, MA, USA.
Anna GrekaBroad Institute of MIT and Harvard, Cambridge, MA, USA; Kidney Disease Initiative, Broad Institute of MIT and Harvard, Cambridge, MA, USA; Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA. Electronic address: agreka@broadinstitute.org.
Funding
Regional Pilot And Feasibility Study Grants ProgramP30DK020572 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Mehboob A Hussain · 2013 to 2026
$24.3MMolecular mechanisms of podocyte injury in FSGSR01DK095045 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI Anna Greka, Juan Lorenzo Pablo · 2014 to 2026
$5.1MRole of TRPC5 channel inhibition in the treatment of glomerular diseaseR01DK099465 · NIDDK · BROAD INSTITUTE, INC. · PI Anna Greka · 2014 to 2026
$5.1MOpera Phenix high-throughput microplate confocal imager for high-content screeningS10OD026839 · OD · BROAD INSTITUTE, INC. · PI WAGNER, BRIDGET K · 2019 to 2019
$1.0MNIDDK NIH HHS P30 DK020572NIDDK NIH HHS R01 DK095045NIDDK NIH HHS R01 DK099465NIH HHS S10 OD026839
Abstract
Diabetic kidney disease (DKD), the most common cause of kidney failure, is a frequent complication of diabetes and obesity, and yet to date, treatments to halt its progression are lacking. We analyze kidney single-cell transcriptomic profiles from DKD patients and two DKD mouse models at multiple time points along disease progression-high-fat diet (HFD)-fed mice aged to 90-100 weeks and BTBR ob/ob mice (a genetic model)-and report an expanding population of macrophages with high expression of triggering receptor expressed on myeloid cells 2 (TREM2) in HFD-fed mice. TREM2
Indexed as
Diabetic NephropathiesDiet, High-FatKidneyMacrophagesMembrane GlycoproteinsMice, KnockoutObesityReceptors, ImmunologicAnimalsFemaleHumansMaleMiceMice, Inbred C57BLMembrane GlycoproteinsReceptors, ImmunologicTREM2 protein, humanTrem2 protein, mouseCP: Immunologydiabetic kidney diseaseimmuneinflammationmacrophagemyeloidsingle-cell transcriptomicsTREM2
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LicenceCC BY-NC
Read underepoch 390
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.