Evidence map›Paper›PMID 38780854›Full record

ArticleNeurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology2024

Diagnostic value of antibody concentration ratio for treatment-refractory myasthenia gravis.

Yi Li, Shumei Yang, Xiaohua Dong, Weiwei Duan, Fei Jiang, Kangzhi Chen, Qian Zhou, Haobin Cai, Huan Yang

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Article in Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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4 · The record

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5 · Who and what money

Authors and funding

9 authors.

Yi LiDepartment of Neurology, Research Center for Neuroimmune and Neuromuscular disorders, Xiangya Hospital, Central South University, 87 Xiangya Road, Changsha, 410000, Hunan, China.
Shumei YangXiangya Hospital, Central South University, 87 Xiangya Road, Changsha, 410000, Hunan, China.
Xiaohua DongDepartment of Neurology, Research Center for Neuroimmune and Neuromuscular disorders, Xiangya Hospital, Central South University, 87 Xiangya Road, Changsha, 410000, Hunan, China.
Weiwei DuanDepartment of Neurology, Research Center for Neuroimmune and Neuromuscular disorders, Xiangya Hospital, Central South University, 87 Xiangya Road, Changsha, 410000, Hunan, China.
Fei JiangDepartment of Neurology, Research Center for Neuroimmune and Neuromuscular disorders, Xiangya Hospital, Central South University, 87 Xiangya Road, Changsha, 410000, Hunan, China.
Kangzhi ChenDepartment of Neurology, Research Center for Neuroimmune and Neuromuscular disorders, Xiangya Hospital, Central South University, 87 Xiangya Road, Changsha, 410000, Hunan, China.
Qian ZhouDepartment of Neurology, Research Center for Neuroimmune and Neuromuscular disorders, Xiangya Hospital, Central South University, 87 Xiangya Road, Changsha, 410000, Hunan, China.
Haobin CaiDepartment of Neurology, Research Center for Neuroimmune and Neuromuscular disorders, Xiangya Hospital, Central South University, 87 Xiangya Road, Changsha, 410000, Hunan, China.
Huan YangDepartment of Neurology, Research Center for Neuroimmune and Neuromuscular disorders, Xiangya Hospital, Central South University, 87 Xiangya Road, Changsha, 410000, Hunan, China. 403850@csu.edu.cn.ORCID http://orcid.org/0000-0002-8690-2544

Funding

National Natural Science Foundation of China 82171399
6 · The paper itself

Abstract

objectiveThis study aimed to assess the diagnostic potential of the Antibody concentration ratio in identifying treatment-refractory myasthenia gravis (MG).

methodsA retrospective analysis was conducted on 116 MG patients who underwent antibody detection at least twice between June 1, 2015, and June 1, 2023. Demographic and clinical characteristics were collated to ascertain their association with refractory MG. The Antibody Concentration Ratio was applied to determine treatment response, using the International Consensus Guidance criteria as the reference standard. The area under nonparametric receiver operating characteristic curve (AUC), sensitivity, specificity, and accuracy were calculated to assess the diagnostic efficacy of the Antibody concentration ratio following consecutive immunotherapy relative to initial antibody concentrations for refractory MG.

results19 out of 116 patients were unequivocally diagnosed with refractory MG. A significant correlation was found between the Antibody Concentration Ratio and refractory MG status in treatment-refractory and treatment-responsive patients. Subsequently, the AUC demonstrated the robust diagnostic capability of the Antibody concentration ratio for refractory MG, with an AUC of 0.8709 (95% CI: 0.7995-0.9422, p < 0.0001). The optimal cut-off value stood at 0.8903, exhibiting a sensitivity of 94.74% (95% CI: 75.36%-99.73%), a specificity of 68.04% (95% CI: 58.23%-76.48%), and accuracy of 72.41% (95% CI: 64.28%-80.54%).

conclusionElevated Antibody Concentration Ratio is intrinsically linked with refractory MG and exhibits potential as an diagnostic biomarker for the condition.

Indexed as

AutoantibodiesMyasthenia GravisAdultAgedFemaleHumansMaleMiddle AgedRetrospective StudiesSensitivity and SpecificityYoung AdultAutoantibodiesDiagnostic valueMyasthenia gravisReceiver operating characteristic curveRefractory

Identifiers

PMID38780854

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