Evidence map›Paper›PMID 38780757›Full record

ReviewCerebellum (London, England)2024

Converging and Diverging Cerebellar Pathways for Motor and Social Behaviors in Mice.

Meike E van der Heijden

Abstract readReview
In one paragraph

Review in Cerebellum (London, England), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author.

Meike E van der HeijdenFralin Biomedical Research Institute, Virginia Tech Carilion, Roanoke, VA, USA. mheijden@vt.edu.

Funding

Defining a Dystonia Specific Spiking Signature in Cerebellar Nuclei CellsK99NS130463 · NINDS · BAYLOR COLLEGE OF MEDICINE · PI VAN DER HEIJDEN, MEIKE ESTHER · 2023 to 2023
$122k
NINDS NIH HHS K99NS13046NINDS NIH HHS K99 NS130463
6 · The paper itself

Abstract

Evidence from clinical and preclinical studies has shown that the cerebellum contributes to cognitive functions, including social behaviors. Now that the cerebellum's role in a wider range of behaviors has been confirmed, the question arises whether the cerebellum contributes to social behaviors via the same mechanisms with which it modulates movements. This review seeks to answer whether the cerebellum guides motor and social behaviors through identical pathways. It focuses on studies in which cerebellar cells, synapses, or genes are manipulated in a cell-type specific manner followed by testing of the effects on social and motor behaviors. These studies show that both anatomically restricted and cerebellar cortex-wide manipulations can lead to social impairments without abnormal motor control, and vice versa. These studies suggest that the cerebellum employs different cellular, synaptic, and molecular pathways for social and motor behaviors. Future studies warrant a focus on the diverging mechanisms by which the cerebellum contributes to a wide range of neural functions.

Indexed as

CerebellumMotor ActivityNeural PathwaysSocial BehaviorAnimalsBehavior, AnimalMiceCerebellumCircuitsGenetic modelsMiceMotor controlSocial behaviors

Identifiers

PMID38780757
PMCPMC11489171

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.