Evidence map›Paper›PMID 38780735›Full record

ArticleMethods in molecular biology (Clifton, N.J.)2024

Evolutionary Structure Conservation and Covariance Scores.

Florian Eggenhofer, Christian Höner Zu Siederdissen

Abstract read
PubMed Publisher
In one paragraph

Article in Methods in molecular biology (Clifton, N.J.), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Florian EggenhoferBioinformatics Group, Department of Computer Science University of Freiburg, Freiburg, Germany.
Christian Höner Zu SiederdissenBioinformatics Group, Department of Computer Science, University of Leipzig, Leipzig, Germany. christian.hoener.zu.siederdissen@uni-jena.de.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Effective homology search for non-coding RNAs is frequently not possible via sequence similarity alone. Current methods leverage evolutionary information like structure conservation or covariance scores to identify homologs in organisms that are phylogenetically more distant. In this chapter, we introduce the theoretical background of evolutionary structure conservation and covariance score, and we show hands-on how current methods in the field are applied on example datasets.

Indexed as

Computational BiologyEvolution, MolecularAlgorithmsAnimalsConserved SequenceHumansPhylogenyRNA, UntranslatedSequence AlignmentSoftwareRNA, UntranslatedCovariance modelsMultiple sequence alignmentRNA familiesSecondary structureUnsupervised model construction

Identifiers

PMID38780735

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.