ArticleAging clinical and experimental research2024
Cognitive trajectories preluding the onset of different dementia entities: a descriptive longitudinal study using the NACC database.
Article in Aging clinical and experimental research, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
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Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Neuropsychological Tests for Detecting Prodromal DLB: A Systematic Review.European journal of neurology · 2026Pooled it
- Blood Biomarkers of Alzheimer Disease and Rates of Global and Domain-Specific Cognitive Decline.JAMA network open · 2026Article
- Modeling small vessel disease burden and vascular dementia likelihood from NACC data.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Do Perspectives Matter? Comparing Patient, Informant, and Clinician Subjective Cognitive Decline.medRxiv : the preprint server for health sciences · 2026Article
- Cognitive Impairment, Dementia and Depression in Older Adults.Journal of clinical medicine · 2026Review
- Neuropathologic Profiles and Associated Cognitive Trajectories in Community-Living Older Adults.JAMA network open · 2026Article
- No associations between blood pressure and brain volumes in a convenience sample of Hispanic/Latino middle-aged and older adults.Frontiers in aging neuroscience · 2026Article
- Associations Between Cognitive Performance and Motor Signs in Older Adults with Alzheimer's Dementia.Medicina (Kaunas, Lithuania) · 2025Article
- Special Issue: "New Insights of Biomarkers in Neurodegenerative Diseases".International journal of molecular sciences · 2025Article
- Factors associated with motor manifestations in older adults with Alzheimer's dementia: a cross-sectional analysis.European geriatric medicine · 2025Article
- Apolipoprotein E Alleles and Motor Signs in Older Adults with Alzheimer's Dementia.International journal of molecular sciences · 2025Article
- Tracking Cognitive Trajectories in Mild Cognitive Impairment Using a Machine Learning Technique of Subtype and Stage Inference.Dementia and neurocognitive disorders · 2025Article
- Web-based assessment of dual-task costs at different ages: an analysis across cognitive domains.Frontiers in psychology · 2025Article
- Blood-Based Biomarkers in Frontotemporal Dementia: A Narrative Review.International journal of molecular sciences · 2024Review
Corrections and comments
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Authors and funding
6 authors.
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Abstract
objectiveTo describe the 10-year preclinical cognitive trajectories of older, non-demented individuals towards the onset of the four most prevalent types of dementia, i.e., Alzheimer's disease(AD), Lewy body(LBD), vascular(VD) and frontotemporal dementia(FTD).
methodsOur analysis focused on data from older (≥ 60years) NACC (National Alzheimer's Coordinating Center) participants. Four distinct presymptomatic dementia groups (AD-LBD-VD-FTD) and a comparison group of cognitively unimpaired(CU) participants were formed. Comprehensive cognitive assessments involving verbal episodic memory, semantic verbal fluency, confrontation naming, mental processing speed - attention and executive function - cognitive flexibility were conducted at baseline and on an approximately yearly basis. Descriptive analyses (adjusted general linear models) were performed to determine and compare the yearly cognitive scores of each group throughout the follow-up. Exploratory analyses were conducted to estimate the rates of cognitive decline.
resultsThere were 3343 participants who developed AD, 247 LBD, 108 FTD, 155 VD and 3398 composed the CU group. Participants with AD performed worse on episodic memory than those with VD and LBD for about 3 to 4 years prior to dementia onset (the FTD group documented an intermediate course). Presymptomatic verbal fluency and confrontation naming trajectories differentiated quite well between the FTD group and the remaining dementia entities. Participants with incident LBD and VD performed worse than those with AD on executive functions and mental processing speed-attention since about 5 years prior to the onset of dementia, and worse than those with FTD more proximally to the diagnosis of the disorder.
conclusionsHeterogeneous cognitive trajectories characterize the presymptomatic courses of the most prevalent dementia entities.
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