Evidence map›Paper›PMID 38780427›Full record

ArticleRadiology. Cardiothoracic imaging2024

Sex Differences in Aging-related Myocardial Stiffening Quantitatively Measured with MR Elastography.

Arvin Arani, Matthew C Murphy, Huzefa Bhopalwala, Shivaram P Arunachalam, Phillip J Rossman, Joshua D Trzasko, Kevin Glaser, Yi Sui, Tina Gunderson, Adelaide M Arruda-Olson and 4 more

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Article in Radiology. Cardiothoracic imaging, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Review
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  4. Radiology. Cardiothoracic imaging · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Arvin AraniFrom the Departments of Radiology (A.A., M.C.M., H.B., S.P.A., P.J.R., J.D.T., K.G., Y.S., A.M., K.K., R.L.E., P.A.A.), Quantitative Health Science (T.G.), and Cardiology (A.M.A.O.), Mayo Clinic, 200 First St SW, Rochester, MN 55905.ORCID 0000-0001-6607-8781
Matthew C MurphyFrom the Departments of Radiology (A.A., M.C.M., H.B., S.P.A., P.J.R., J.D.T., K.G., Y.S., A.M., K.K., R.L.E., P.A.A.), Quantitative Health Science (T.G.), and Cardiology (A.M.A.O.), Mayo Clinic, 200 First St SW, Rochester, MN 55905.
Huzefa BhopalwalaFrom the Departments of Radiology (A.A., M.C.M., H.B., S.P.A., P.J.R., J.D.T., K.G., Y.S., A.M., K.K., R.L.E., P.A.A.), Quantitative Health Science (T.G.), and Cardiology (A.M.A.O.), Mayo Clinic, 200 First St SW, Rochester, MN 55905.ORCID 0000-0002-4289-7288
Shivaram P ArunachalamFrom the Departments of Radiology (A.A., M.C.M., H.B., S.P.A., P.J.R., J.D.T., K.G., Y.S., A.M., K.K., R.L.E., P.A.A.), Quantitative Health Science (T.G.), and Cardiology (A.M.A.O.), Mayo Clinic, 200 First St SW, Rochester, MN 55905.ORCID 0000-0003-3251-5415
Phillip J RossmanFrom the Departments of Radiology (A.A., M.C.M., H.B., S.P.A., P.J.R., J.D.T., K.G., Y.S., A.M., K.K., R.L.E., P.A.A.), Quantitative Health Science (T.G.), and Cardiology (A.M.A.O.), Mayo Clinic, 200 First St SW, Rochester, MN 55905.ORCID 0000-0002-3245-4934
Joshua D TrzaskoFrom the Departments of Radiology (A.A., M.C.M., H.B., S.P.A., P.J.R., J.D.T., K.G., Y.S., A.M., K.K., R.L.E., P.A.A.), Quantitative Health Science (T.G.), and Cardiology (A.M.A.O.), Mayo Clinic, 200 First St SW, Rochester, MN 55905.ORCID 0000-0001-8180-5449
Kevin GlaserFrom the Departments of Radiology (A.A., M.C.M., H.B., S.P.A., P.J.R., J.D.T., K.G., Y.S., A.M., K.K., R.L.E., P.A.A.), Quantitative Health Science (T.G.), and Cardiology (A.M.A.O.), Mayo Clinic, 200 First St SW, Rochester, MN 55905.
Yi SuiFrom the Departments of Radiology (A.A., M.C.M., H.B., S.P.A., P.J.R., J.D.T., K.G., Y.S., A.M., K.K., R.L.E., P.A.A.), Quantitative Health Science (T.G.), and Cardiology (A.M.A.O.), Mayo Clinic, 200 First St SW, Rochester, MN 55905.ORCID 0000-0002-8177-1661
Tina GundersonFrom the Departments of Radiology (A.A., M.C.M., H.B., S.P.A., P.J.R., J.D.T., K.G., Y.S., A.M., K.K., R.L.E., P.A.A.), Quantitative Health Science (T.G.), and Cardiology (A.M.A.O.), Mayo Clinic, 200 First St SW, Rochester, MN 55905.
Adelaide M Arruda-OlsonFrom the Departments of Radiology (A.A., M.C.M., H.B., S.P.A., P.J.R., J.D.T., K.G., Y.S., A.M., K.K., R.L.E., P.A.A.), Quantitative Health Science (T.G.), and Cardiology (A.M.A.O.), Mayo Clinic, 200 First St SW, Rochester, MN 55905.ORCID 0000-0001-9541-9899
Armando ManducaFrom the Departments of Radiology (A.A., M.C.M., H.B., S.P.A., P.J.R., J.D.T., K.G., Y.S., A.M., K.K., R.L.E., P.A.A.), Quantitative Health Science (T.G.), and Cardiology (A.M.A.O.), Mayo Clinic, 200 First St SW, Rochester, MN 55905.ORCID 0000-0002-9411-5671
Kejal KantarciFrom the Departments of Radiology (A.A., M.C.M., H.B., S.P.A., P.J.R., J.D.T., K.G., Y.S., A.M., K.K., R.L.E., P.A.A.), Quantitative Health Science (T.G.), and Cardiology (A.M.A.O.), Mayo Clinic, 200 First St SW, Rochester, MN 55905.
Richard L EhmanFrom the Departments of Radiology (A.A., M.C.M., H.B., S.P.A., P.J.R., J.D.T., K.G., Y.S., A.M., K.K., R.L.E., P.A.A.), Quantitative Health Science (T.G.), and Cardiology (A.M.A.O.), Mayo Clinic, 200 First St SW, Rochester, MN 55905.ORCID 0000-0001-7041-5074
Philip A AraozFrom the Departments of Radiology (A.A., M.C.M., H.B., S.P.A., P.J.R., J.D.T., K.G., Y.S., A.M., K.K., R.L.E., P.A.A.), Quantitative Health Science (T.G.), and Cardiology (A.M.A.O.), Mayo Clinic, 200 First St SW, Rochester, MN 55905.ORCID 0000-0001-5465-7997

Funding

Mayo Clinic Interdisciplinary Women's Health Research ProgramK12HD065987 · NICHD · MAYO CLINIC ROCHESTER · PI KANTARCI, KEJAL · 2010 to 2023
$6.7M
Magnetic Resonance ElastographyR37EB001981 · NIBIB · MAYO CLINIC ROCHESTER · PI EHMAN, RICHARD L. · 2016 to 2025
$4.0M
Magnetic Resonance ElastographyR01EB001981 · NIBIB · MAYO CLINIC ROCHESTER · PI EHMAN, RICHARD L. · 2003 to 2013
$3.1M
Evaluating the natural evolution of myocardial stiffness in aging, sex differences, and through menopause transition in women, using a free-breathing magnetic resonance elastography approachR01HL151379 · NHLBI · MAYO CLINIC ROCHESTER · PI Arvin Forghanian-Arani · 2023 to 2026
$2.3M
Cardiac Magnetic Resonance Elastography: Imaging Heart Failure PathophysiologyR01HL115144 · NHLBI · MAYO CLINIC ROCHESTER · PI ARAOZ, PHILIP ALEXANDER · 2012 to 2016
$2.0M
Advancing MR elastography to map mechanical signatures of key AD/ADRD processesR01AG076636 · NIA · MAYO CLINIC ROCHESTER · PI Matthew Christopher Murphy · 2023 to 2026
$1.8M
Advanced preoperative assessment of meningiomasR01EB027064 · NIBIB · MAYO CLINIC ROCHESTER · PI MURPHY, MATTHEW CHRISTOPHER · 2019 to 2022
$1.4M
NHLBI NIH HHS R01 HL115144NHLBI NIH HHS R01 HL151379NIA NIH HHS R01 AG076636NIBIB NIH HHS R01 EB001981NIBIB NIH HHS R01 EB027064NIBIB NIH HHS R37 EB001981NICHD NIH HHS K12 HD065987
6 · The paper itself

Abstract

Purpose To investigate the feasibility of using quantitative MR elastography (MRE) to characterize the influence of aging and sex on left ventricular (LV) shear stiffness. Materials and Methods In this prospective study, LV myocardial shear stiffness was measured in 109 healthy volunteers (age range: 18-84 years; mean age, 40 years ± 18 [SD]; 57 women, 52 men) enrolled between November 2018 and September 2019, using a 5-minute MRE acquisition added to a clinical MRI protocol. Linear regression models were used to estimate the association of cardiac MRI and MRE characteristics with age and sex; models were also fit to assess potential age-sex interaction. Results Myocardial shear stiffness significantly increased with age in female (age slope = 0.03 kPa/year ± 0.01,

Indexed as

AgingElasticity Imaging TechniquesHeart VentriclesAdolescentAdultAgedAged, 80 and overFeasibility StudiesFemaleHumansMagnetic Resonance ImagingMaleMiddle AgedProspective StudiesSex FactorsVentricular Function, LeftAging HeartBiological EffectsCardiacCardiac MREElastographyExperimental InvestigationsMR ElastographyMyocardial BiomechanicsMyocardial Shear StiffnessQuantitative Stiffness ImagingSexual Dimorphisms

Identifiers

PMID38780427
PMCPMC11211939

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.