ArticleWorld journal for pediatric & congenital heart surgery2024
Surgical Protocol for Partial Heart Transplantation in Growing Piglets.
Article in World journal for pediatric & congenital heart surgery, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- Intramuscular Tacrolimus Pharmacokinetics in a Pediatric Porcine Model for Partial Heart Transplantation.Transplantation proceedings · 2025Article
- Partial Heart Transplants Require Immunosuppression in Growing Piglets.Transplantation · 2025Article
- Animal models for partial heart transplantation.Pediatric transplantation · 2024Review
- Improving long-term postoperative survival in a porcine cardiac valve surgery model utilizing cardiopulmonary bypass via left thoracotomy: a single-center experience sharing insights.Frontiers in cardiovascular medicine · 2024Article
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Authors and funding
20 authors.
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Abstract
Partial heart transplantation is a new approach to deliver growing heart valve implants. Partial heart transplants differ from heart transplants because only the part of the heart containing the necessary heart valve is transplanted. This allows partial heart transplants to grow, similar to the valves in heart transplants. However, the transplant biology of partial heart transplantation remains unexplored. This is a critical barrier to progress of the field. Without knowledge about the specific transplant biology of partial heart transplantation, children with partial heart transplants are empirically treated like children with heart transplants because the valves in heart transplants are known to grow. In order to progress the field, an animal model for partial heart transplantation is necessary. Here, we contribute our surgical protocol for partial heart transplantation in growing piglets. All aspects of partial heart transplantation, including the donor procedure, the recipient procedure, and recipient perioperative care are described in detail. There are important nuances in the conduct of virtually all aspects of open heart surgery that differs in piglets from humans. Our surgical protocol, which is based on our experience with 34 piglets, will allow other investigators to leverage our experience to seek fundamental knowledge about the nature of partial heart transplants. This is significant because the partial heart transplant model in piglets is complex and very resource intensive.
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