ArticleJournal of the American Heart Association2024
Bidirectional Association Between Atrial Fibrillation and Myocardial Infarction, and Relation to Mortality in the Framingham Heart Study.
Article in Journal of the American Heart Association, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- NovelBiomedicines · 2026Article
- Atrial fibrillation and risk of myocardial infarction by sex and time since diagnosis. The Tromsø Study 1994-2021.European heart journal. Quality of care & clinical outcomes · 2026Article
- Rare TruncatingGenes · 2026Article
- Insights Into Cardiovascular Disease in Women From the Framingham Heart Study.JACC. Advances · 2026Article
- Predicting common cardiovascular and non-cardiovascular outcomes after new-onset atrial fibrillation: an analysis from a UK nationwide primary-secondary care linkage dataset.European heart journal open · 2026Article
- Age-Stratified Mortality Impact of Atrial Fibrillation in Elderly NSTEMI Patients.Journal of cardiovascular development and disease · 2026Article
- Discovery ofDiagnostics (Basel, Switzerland) · 2025Article
- Article
- The relationship between homocysteine and new-onset atrial fibrillation in patients with acute myocardial infarction.Annals of medicine · 2025Article
- Association of C₂HEST Score and New-Onset Atrial Fibrillation in Patients with Non-ST-Segment Elevation Myocardial Infarction.Medical science monitor : international medical journal of experimental and clinical research · 2025Article
- Validation of a Novel Risk Prediction Score for Sudden Cardiac Death in the Framingham Heart Study.Circulation. Arrhythmia and electrophysiology · 2025Article
- Identification and Functional Investigation ofDiagnostics (Basel, Switzerland) · 2024Article
- Atrial fibrillation and acute coronary syndrome.EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology · 2024Article
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Authors and funding
9 authors.
Funding
Abstract
backgroundIndividuals with both atrial fibrillation (AF) and myocardial infarction (MI) have higher mortality compared with individuals with only 1 condition. Whether mortality differs according to the temporal order of AF and MI is unclear. METHODS AND
resultsWe included participants from the FHS (Framingham Heart Study) from 1960 and onwards. We assessed the hazard ratio (HR) of new-onset AF and MI, and mortality according to MI and AF status (prevalent and interim) using multivariable-adjusted Cox proportional hazards models. Interim diseases were modeled as time-varying variables. For the analysis of new-onset AF, 10 923 participants (55% women; mean±SD age, 54±8 years) were included. For new-onset MI, 10 804 participants (55% women; mean±SD age, 54±8 years) were included. Compared with no MI, the hazard of new-onset AF was higher in participants with prevalent (HR, 1.60 [95% CI, 1.32-1.94]) and interim MI (HR, 3.96 [95% CI, 3.18-4.91]). Both ST-segment-elevation MI and non-ST-segment-elevation MI were associated with new-onset AF. Interim AF, not prevalent AF, was associated with higher hazard rate of new-onset MI (HR, 2.21 [95% CI, 1.67-2.92]). Interim AF was associated with both ST-segment-elevation MI and non-ST-segment-elevation MI. Mortality was significantly greater among participants with AF and MI compared with participants with 1 of the 2, regardless of temporal order.
conclusionsWe report a bidirectional association between AF and MI, which was observed for both non-ST-segment-elevation MI and ST-segment-elevation MI. Participants with both AF and MI had considerably higher mortality compared with participants with only 1 of the 2 conditions, regardless of order.
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