ArticleImmunity, inflammation and disease2024
Bioinformatics investigation of adaptive immune-related genes in peri-implantitis and periodontitis: Characteristics and diagnostic values.
Article in Immunity, inflammation and disease, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 2 of them syntheses that pooled it.
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Who cites it
11 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Clinical implications of dysregulated non-coding RNA expression in periodontitis: evidence synthesis from a systematic review and meta-analysis.Odontology · 2026Pooled it
- Transcriptomic and Metagenomic Biomarkers in Peri-Implantitis: A Systematic Review, Diagnostic Meta-Analysis, and Functional Meta-Synthesis.Medical sciences (Basel, Switzerland) · 2025Pooled it
- Peri-Implantitis and Periodontitis: Biological Convergence, Contextual Divergence.Journal of periodontal research · 2026Review
- A Comparative Bioinformatics Analysis of the Transcriptomic Profiles of Peri-Implantitis and Periodontitis and Their Common Signaling Pathways with Atherosclerosis.Current issues in molecular biology · 2026Article
- Integrated bioinformatics and machine learning to explore the common mechanisms and potential biomarkers between periodontitis and preterm birth.Frontiers in cell and developmental biology · 2026Article
- Impaired Treg-Mediated Immune Regulation in Peri-Implantitis Lesions and Implant Loss: Insights From Histological and Molecular Analyses.Journal of clinical periodontology · 2025Article
- Exploring the Shared Genetic Characteristics of Peri-Implantitis and Osteoporosis: A Transcriptomic Analysis Perspective.International dental journal · 2025Article
- Integration of Bioinformatics and Machine Learning Strategies Identifies Ferroptosis and Immune Infiltration Signatures in Peri-Implantitis.International journal of molecular sciences · 2025Article
- Bioinformatics investigation of adaptive immune-related genes in peri-implantitis and periodontitis: Characteristics and diagnostic values.Immunity, inflammation and disease · 2024Article
- Titanium nanotubes modulate immunophenotyping and cytokine secretion of T cells via IL-17A: a bioinformatic analysis and experimental validation.Frontiers in immunology · 2024Article
- Role of immune dysregulation in peri-implantitis.Frontiers in immunology · 2024Review
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
backgroundPeri-implantitis and periodontitis have similar immunological bioprocesses and inflammatory phenotypes. In the inflammatory process, the adaptive immune cells can drive the development of disease. This research investigated the differences and diagnostic significance of peri-implantitis and periodontitis in adaptive immune responses.
methodsWe acquired four GEO datasets of gene expressions in surrounding tissues in healthy person, healthy implant, periodontitis, and peri-implantitis patients. The structural characteristics and enrichment analyses of differential expression genes were examined. The adaptive immune landscapes in peri-implantitis and periodontitis were then evaluated using single sample gene set enrichment analysis. The STRING database and Cytoscape were used to identify adaptive hub genes, and the ROC curve was used to verify them. Finally, qRT-PCR method was used to verify the expression level of Hub gene in activated T cells on the titanium-containing or titanium-free culture plates.
resultsAt the transcriptome level, the data of healthy implant, peri-implantitis and periodontitis were highly dissimilar. The peri-implantitis and periodontitis both exhibited adaptive immune response. Except for the activated CD4
conclusionsPeri-implantitis has a uniquely immunogenomic landscape that differs from periodontitis. This study provides new insights and ideas into the activated CD4
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