Evidence map›Paper›PMID 38779749›Full record

ArticleBrain and behavior2024

The impact of neurocognitive and psychiatric disorders on the risk of idiopathic normal pressure hydrocephalus: A bidirectional Mendelian randomization study.

Yuze He, Zhihao Wang, Mingrong Zuo, Shuxin Zhang, Wenhao Li, Siliang Chen, Yunbo Yuan, Yuan Yang, Yanhui Liu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Brain and behavior, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Genetic Risk Factors in Normal Pressure Hydrocephalus: What We Know and What Is Next.Movement disorders : official journal of the Movement Disorder Society · 2025
    Pooled it
  2. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Yuze HeDepartment of Neurosurgery, West China Hospital, Sichuan University, Chengdu, China.ORCID 0009-0005-6255-6199
Zhihao WangDepartment of Neurosurgery, West China Hospital, Sichuan University, Chengdu, China.
Mingrong ZuoDepartment of Pediatric Neurosurgery, West China Women's and Children's Hospital, Sichuan University West China Second University Hospital, Chengdu, China.
Shuxin ZhangDepartment of Critical Care Medicine, West China Hospital, Sichuan University, Chengdu, China.
Wenhao LiDepartment of Neurosurgery, West China Hospital, Sichuan University, Chengdu, China.
Siliang ChenDepartment of Neurosurgery, West China Hospital, Sichuan University, Chengdu, China.
Yunbo YuanDepartment of Neurosurgery, West China Hospital, Sichuan University, Chengdu, China.
Yuan YangDepartment of Neurosurgery, West China Hospital, Sichuan University, Chengdu, China.
Yanhui LiuDepartment of Neurosurgery, West China Hospital, Sichuan University, Chengdu, China.

Funding

The Sichuan Provincial Foundation of Science and Technology (2023NSFSC1867 to SXZ)The Sichuan Science and Technology Program (2023YFG0127 to Y Y)The Sichuan Science and Technology Program (2023YFQ0002 to YH L)
6 · The paper itself

Abstract

backgroundNeurocognitive and psychiatric disorders have been proved that they can comorbid more often with idiopathic normal pressure hydrocephalus (iNPH) than general population. However, the potential causal association between these disorders and iNPH has not been assessed. Thus, our study aims to investigate the causal relationship between them based on a bidirectional Mendelian randomization (MR) analysis.

methodsRandom effects of the inverse variance weighted (IVW) method were conducted to obtain the causal association among the neurocognitive disorders, psychiatric disorders, and iNPH. Genome-wide association studies (GWAS) of 12 neurocognitive and psychiatric disorders were downloaded via the OpenGWAS database, GWAS Catalog, and Psychiatric Genomics Consortium, whereas GWAS data of iNPH were obtained from the FinnGen consortium round 9 release, with 767 cases and 375,610 controls of European ancestry. We also conducted the sensitivity analysis in these significant causal inferences using weighted median model, Cochrane's Q test, MR-Egger regression, MR Pleiotropy Residual Sum and Outlier detect and the leave-one-out analysis.

resultsFor most of the neurocognitive and psychiatric disorders, no causal association was established between them and iNPH. We have found that iNPH (odds ratio [OR] = 1.030, 95% confidence interval [CI]: 1.011-1.048, p = .001) is associated with increased risk for schizophrenia, which failed in validation of sensitivity analysis. Notably, genetically predicted Parkinson's disease (PD) is associated with increased risk of iNPH (OR = 1.256, 95% CI: 1.045-1.511, p = .015).

conclusionOur study has revealed the potential causal effect in which PD associated with an increased risk of iNPH. Further study is warranted to investigate the association between PD and iNPH and the potential underlying mechanism.

Indexed as

Genome-Wide Association StudyHydrocephalus, Normal PressureMendelian Randomization AnalysisMental DisordersHumansNeurocognitive Disordersidiopathic normal pressure hydrocephalusMendelian randomizationneuropsychiatric disordersneuropsychiatric symptoms

Identifiers

PMID38779749
PMCPMC11112403

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.