ArticleFrontiers in immunology2024
Troxerutin suppress inflammation response and oxidative stress in jellyfish dermatitis by activating Nrf2/HO-1 signaling pathway.
Article in Frontiers in immunology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- Anti-Pruritic and Analgesic Effects of a Topical Formulation Containing Troxerutin: A Pilot Study.Journal of cosmetic dermatology · 2025Article
- Tie2-mediated CBL ubiquitination of EGFR underlies ultrasound-responsive silk fibroin/graphene oxide hydrogel-troxerutin therapy for intervertebral disc degeneration.Materials today. Bio · 2025Article
- Jellyfish Venom-Induced Cardiotoxicity and Immune Responses: Mechanisms and Potential Therapeutic Strategies.Marine drugs · 2025Review
- Advances in Jellyfish Sting Mechanisms and Treatment Strategies.Marine drugs · 2025Review
- Jingfang Granules for Diabetic Wound Healing: Insights from Network Pharmacology and Experimental Validation.Drug design, development and therapy · 2025Article
Corrections and comments
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Authors and funding
7 authors.
Funding
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Abstract
Background: Methods: We examined the inhibit effects of the TRX on tentacle extract (TE) obtained from Results: TE significantly induced the mice paw skin toxicity and accumulation of inflammatory cytokines and reactive oxygen species in vivo and vitro. Moreover, a robust increase in the phosphorylation of mitogen-activated protein kinase (MAPKs) and nuclear factor-kappa B (NF-κB) signaling pathways was observed. While, the acute cutaneous inflammation and oxidative stress induced by TE were significantly ameliorated by TRX treatment. Notablly, TRX suppressed the phosphorylation of MAPK and NF-κB by initiating the nuclear factor erythroid 2-related factor 2 signaling pathway, which result in decreasing inflammatory cytokine release. Conclusion: TRX inhibits the major signaling pathway responsible for inducing inflammatory and oxidative damage of jellyfish dermatitis, offering a novel therapy in clinical applications.
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