Evidence map›Paper›PMID 38779668›Full record

ReviewFrontiers in immunology2024

Outpatient administration of CAR T-cell therapy: a focused review with recommendations for implementation in community based centers.

Ariel Perez, Tiba Al Sagheer, George R Nahas, Yuliya P L Linhares

Abstract readReview
In one paragraph

Review in Frontiers in immunology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Trial
  2. Article
  3. Article
  4. Review
  5. Article
  6. Review
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  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Ariel PerezMiami Cancer Institute, Baptist Hospital of Miami, Miami, FL, United States.
Tiba Al SagheerMiami Cancer Institute, Baptist Hospital of Miami, Miami, FL, United States.
George R NahasMiami Cancer Institute, Baptist Hospital of Miami, Miami, FL, United States.
Yuliya P L LinharesMiami Cancer Institute, Baptist Hospital of Miami, Miami, FL, United States.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Chimeric Antigen Receptor T-cell (CAR-T) therapy has transformed the treatment landscape for hematological malignancies, showing high efficacy in patients with relapsed or refractory (R/R) disease and otherwise poor prognosis in the pre-CAR-T era. These therapies have been usually administered in the inpatient setting due to the risk of cytokine release syndrome (CRS) and immune effector cell-associated neurotoxicity syndrome (ICANS). However, there is a growing interest in the transition to outpatient administration due to multiple reasons. We review available evidence regarding safety and feasibility of outpatient administration of CD19 targeted and BCMA targeted CAR T-cell therapy with an emphasis on the implementation of outpatient CAR-T programs in community-based centers.

Indexed as

Immunotherapy, AdoptiveAmbulatory CareAntigens, CD19Community Health CentersCytokine Release SyndromeHematologic NeoplasmsHumansOutpatientsReceptors, Chimeric AntigenAntigens, CD19Receptors, Chimeric Antigencellular therapychimeric antigen receptor (CAR T)community basedimplementationoutpatient setting

Identifiers

PMID38779668
PMCPMC11109356

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.