Evidence map›Paper›PMID 38779638›Full record

ArticleAnnals of gastroenterology

Pre-left ventricular assist device endoscopic evaluation does not reduce the risk of later gastrointestinal bleeding: a multicenter study.

Jiahao Peng, Samanthika Devalaraju, Mohamed Azab, William T Cates, Molly Stone, Jonathan Reichstein, Sneha Shaha, Subhasis Chatterjee, Andrew B Civitello, Mourad H Senussi and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Annals of gastroenterology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Jiahao PengCenter for Health Research, Loma Linda University Health, Loma Linda, California (Jiahao Peng).
Samanthika DevalarajuDepartment of Internal Medicine, Baylor College of Medicine, Houston, Texas (Samanthika Devalaraju).
Mohamed AzabDepartment of Gastroenterology, Prevea Health, Hobart, Wisconsin (Mohamed Azab).
William T CatesDepartment of Anesthesiology, Baylor of College, Houston, Texas (William T. Cates).
Molly StoneUniversity of Michigan, Ann Arbor, Michigan (Molly Stone).
Jonathan ReichsteinDivision of Gastroenterology and Hepatology, Medical University of South Carolina, Charleston, South Carolina (Jonathan Reichstein, B. Joseph Elmunzer).
Sneha ShahaDepartment of Medicine, University of California, Los Angeles, Los Angeles, California (Sneha Shaha).
Subhasis ChatterjeeMichael E. DeBakey Department of Surgery, Baylor College of Medicine, Houston, Texas (Subhasis Chatterjee).
Andrew B CivitelloDivision of Cardiology, Department of Internal Medicine, Baylor College of Medicine, Houston, Texas (Andrew B Civitelloj, Mourad H. Senussi).
Mourad H SenussiDivision of Cardiology, Department of Internal Medicine, Baylor College of Medicine, Houston, Texas (Andrew B Civitelloj, Mourad H. Senussi).
B Joseph ElmunzerDivision of Gastroenterology and Hepatology, Medical University of South Carolina, Charleston, South Carolina (Jonathan Reichstein, B. Joseph Elmunzer).
Michael VolkDepartment of Medicine, Baylor Scott and White Health, Central Texas Region (Michael Volk).
Wasseem SkefSection of Gastroenterology and Hepatology, Michael E. DeBakey VA Medical Center, Baylor College of Medicine, Houston, Texas (Wasseem Skef), USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Gastrointestinal bleeding (GIB) is a common complication after placement of a left ventricular assist device (LVAD). Some institutions attempt to mitigate post-LVAD GIB using preoperative endoscopy. Our study evaluated whether preoperative endoscopy was associated with a lower risk of post-LVAD GIB. Methods: This was a multicenter cohort study of patients who underwent LVAD insertion from 2010-2019 at 3 academic sites. A total of 398 study participants were categorized based on whether they underwent preoperative endoscopy or not. The follow-up period was 1 year and the primary outcome was GIB. Secondary outcomes were severe bleeding and intraprocedural complications. Results: A total of 114 patients experienced GIB within 1 year, with a higher rate in the endoscopy cohort (36.4% vs. 24.8%, P=0.015). After adjusting for covariables, the endoscopy cohort remained at increased risk of GIB (adjusted odds ratio 1.77, 95% confidence interval 1.05-2.976; P=0.032). Severe bleeding was common (47.4%). Arteriovenous malformations (48 cases) and peptic ulcer disease (17 cases) were the most identified sources of GIB. Only 1 minor adverse event occurred during preoperative endoscopy. Conclusions: Our study suggests that pre-LVAD endoscopy is associated with a higher risk of GIB post LVAD, despite controlling for confounders. While this was an observational study and may not have captured all confounders, it appears that endoscopic screening may not be warranted.

Indexed as

endoscopygastrointestinal hemorrhageHeart-assist devices

Identifiers

PMID38779638
PMCPMC11107400

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.