Evidence map›Paper›PMID 38779606›Full record

ArticleJournal of cytology

Can Mitotic Figures in Hyperchromatic Crowded Groups be Cytodiagnostic Criteria for High-Grade Squamous Intra-epithelial Lesions?

Hisae Suzuki, Yumeno Kondo, Chihiro Oda, Takeshi Nishikawa, Mao Takeuchi, Shigenobu Tatsumi, Sho Hosokawa, Satoshi Irino, Tomoko Uchiyama, Tomomi Fujii and 1 more

Abstract read
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In one paragraph

Article in Journal of cytology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Hisae SuzukiDepartment of Pathology, Nara Medical University Hospital, Nara, Japan.
Yumeno KondoDepartment of Medical Technology, The Graduate School of Ehime Prefectural University of Health Sciences, Ehime, Japan.
Chihiro OdaDepartment of Medical Technology, The Graduate School of Ehime Prefectural University of Health Sciences, Ehime, Japan.
Takeshi NishikawaDepartment of Pathology, Nara Medical University Hospital, Nara, Japan.
Mao TakeuchiDepartment of Pathology, Nara Medical University Hospital, Nara, Japan.
Shigenobu TatsumiDepartment of Pathology, Nara Medical University Hospital, Nara, Japan.
Sho HosokawaDepartment of Medical Technology, The Graduate School of Ehime Prefectural University of Health Sciences, Ehime, Japan.
Satoshi IrinoDepartment of Nursing, Faculty of Health Sciences, Ehime Prefectural University of Health Sciences, Ehime, Japan.
Tomoko UchiyamaDepartment of Diagnostic Pathology, Nara Medical University, Nara, Japan.
Tomomi FujiiDepartment of Diagnostic Pathology, Nara Medical University, Nara, Japan.
Yoshiaki NorimatsuDepartment of Medical Technology, The Graduate School of Ehime Prefectural University of Health Sciences, Ehime, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Aims: The present study aimed to investigate whether the presence of mitoses in hyperchromatic crowded groups (HCGs) in cervical cytological specimens can serve as cytological criteria for high-grade squamous intra-epithelial lesions (HSILs). Methods and Material: Various parameters were examined, including the frequency of mitotic figures per high power field (HPF) in Pap, hematoxylin eosin (HE) samples, and PHH3 immunocytochemical (ICC) and immunohistochemical (IHC) analyses. Results: In the Pap and PHH3-ICC samples, the number of mitotic figures observed in HCGs was significantly higher in HSIL ( Conclusions: Hence, the presence of two or more mitotic figures in HCGs per HPF in cervical cytology indicates a suspicion of HSIL. The detection of mitoses in PHH3-ICC samples is more sensitive and easier to observe than in Pap samples, making it a valuable mitotic marker.

Indexed as

Cytodiagnostic criteriaendocervical cytologyhigh-grade squamous intra-epithelial lesionshyperchromatic crowded groupsmitotic figures

Identifiers

PMID38779606
PMCPMC11108039

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.