Evidence map›Paper›PMID 38779556›Full record

ArticleMaterials today. Bio2024

Bioinspired core-shell nanofiber drug-delivery system modulates osteogenic and osteoclast activity for bone tissue regeneration.

Shabnam Anjum, Yulin Wang, Yuan Xin, Xiao Li, Ting Li, Hengtong Zhang, Liang Quan, Ya Li, Dilip Kumar Arya, P S Rajinikanth and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Materials today. Bio, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Shabnam AnjumDepartment of Tissue Engineering, School of Intelligent Medicine, China Medical University, Shenyang, Liaoning, 110122, China.
Yulin WangNMPA Key Laboratory for Quality Research and Control of Tissue Regenerative Biomaterial & Institute of Regulatory Science for Medical Device & National Engineering Research Centre for Biomaterials, Sichuan University, Chengdu, Sichuan, 610064, China.
Yuan XinNMPA Key Laboratory for Quality Research and Control of Tissue Regenerative Biomaterial & Institute of Regulatory Science for Medical Device & National Engineering Research Centre for Biomaterials, Sichuan University, Chengdu, Sichuan, 610064, China.
Xiao LiDepartment of Tissue Engineering, School of Intelligent Medicine, China Medical University, Shenyang, Liaoning, 110122, China.
Ting LiDepartment of Laboratory Medicine, Shengjing Hospital of China Medical University, Shenyang, Liaoning, China.
Hengtong ZhangNMPA Key Laboratory for Quality Research and Control of Tissue Regenerative Biomaterial & Institute of Regulatory Science for Medical Device & National Engineering Research Centre for Biomaterials, Sichuan University, Chengdu, Sichuan, 610064, China.
Liang QuanNMPA Key Laboratory for Quality Research and Control of Tissue Regenerative Biomaterial & Institute of Regulatory Science for Medical Device & National Engineering Research Centre for Biomaterials, Sichuan University, Chengdu, Sichuan, 610064, China.
Ya LiNMPA Key Laboratory for Quality Research and Control of Tissue Regenerative Biomaterial & Institute of Regulatory Science for Medical Device & National Engineering Research Centre for Biomaterials, Sichuan University, Chengdu, Sichuan, 610064, China.
Dilip Kumar AryaDepartment of Pharmaceutical Sciences, Babasaheb Bhimrao Ambedkar University, Vidya Vihar, Raebareli Road, Lucknow, India.
P S RajinikanthDepartment of Pharmaceutical Sciences, Babasaheb Bhimrao Ambedkar University, Vidya Vihar, Raebareli Road, Lucknow, India.
Qiang AoDepartment of Tissue Engineering, School of Intelligent Medicine, China Medical University, Shenyang, Liaoning, 110122, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Osteogenic-osteoclast coupling processes play a crucial role in bone regeneration. Recently, strategies that focus on multi-functionalized implant surfaces to enhance the healing of bone defects through the synergistic regulation of osteogenesis and osteoclastogenesis is still a challenging task in the field of bone tissue engineering. The aim of this study was to create a dual-drug release-based core-shell nanofibers with the intent of achieving a time-controlled release to facilitate bone regeneration. We fabricated core-shell P/PCL nanofibers using coaxial electrospinning, where alendronate (ALN) was incorporated into the core layer and hydroxyapatite (HA) into shell. The surface of the nanofiber construct was further modified with mussel-derived polydopamine (PDA) to induce hydrophilicity and enhance cell interactions. Surface characterizations confirmed the successful synthesis of PDA@PHA/PCL-ALN nanofibers endowed with excellent mechanical strength (20.02 ± 0.13 MPa) and hydrophilicity (22.56°), as well as the sustained sequential release of ALN and Ca ions.

Indexed as

Bone regenerationCore-shell nanofiberMussel-derived polydopamineOsteoclastogenesisPCLPLGA

Identifiers

PMID38779556
PMCPMC11109009

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.