Evidence map›Paper›PMID 38779347›Full record

ReviewRegenerative biomaterials2024

Biomaterials for immunomodulation in wound healing.

Ying Wang, Katrina Vizely, Chen Yu Li, Karen Shen, Amid Shakeri, Ramak Khosravi, James Ryan Smith, Eugene Alfonzo I I Alteza, Yimu Zhao, Milica Radisic

Abstract readReview
In one paragraph

Review in Regenerative biomaterials, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed.

  1. Article
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  6. The dual role of the microbiome in chronic wound management.Cell communication and signaling : CCS · 2026
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Ying WangInstitute of Biomedical Engineering, University of Toronto, Toronto, ON M5S 3G9, Canada.ORCID https://orcid.org/0000-0001-6749-3848
Katrina VizelyDepartment of Chemical Engineering and Applied Chemistry, University of Toronto, Toronto, ON M5S 3E5, Canada.
Chen Yu LiDepartment of Chemical Engineering and Applied Chemistry, University of Toronto, Toronto, ON M5S 3E5, Canada.
Karen ShenToronto General Research Institute, University Health Network, Toronto, ON M5G 2C4 Canada.ORCID https://orcid.org/0009-0005-6618-9795
Amid ShakeriInstitute of Biomedical Engineering, University of Toronto, Toronto, ON M5S 3G9, Canada.
Ramak KhosraviToronto General Research Institute, University Health Network, Toronto, ON M5G 2C4 Canada.
James Ryan SmithInstitute of Biomedical Engineering, University of Toronto, Toronto, ON M5S 3G9, Canada.
Eugene Alfonzo I I AltezaInstitute of Biomedical Engineering, University of Toronto, Toronto, ON M5S 3G9, Canada.
Yimu ZhaoInstitute of Biomedical Engineering, University of Toronto, Toronto, ON M5S 3G9, Canada.
Milica RadisicInstitute of Biomedical Engineering, University of Toronto, Toronto, ON M5S 3G9, Canada.ORCID https://orcid.org/0000-0003-1249-4135

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The substantial economic impact of non-healing wounds, scarring, and burns stemming from skin injuries is evident, resulting in a financial burden on both patients and the healthcare system. This review paper provides an overview of the skin's vital role in guarding against various environmental challenges as the body's largest protective organ and associated developments in biomaterials for wound healing. We first introduce the composition of skin tissue and the intricate processes of wound healing, with special attention to the crucial role of immunomodulation in both acute and chronic wounds. This highlights how the imbalance in the immune response, particularly in chronic wounds associated with underlying health conditions such as diabetes and immunosuppression, hinders normal healing stages. Then, this review distinguishes between traditional wound-healing strategies that create an optimal microenvironment and recent peptide-based biomaterials that modulate cellular processes and immune responses to facilitate wound closure. Additionally, we highlight the importance of considering the stages of wounds in the healing process. By integrating advanced materials engineering with an in-depth understanding of wound biology, this approach holds promise for reshaping the field of wound management and ultimately offering improved outcomes for patients with acute and chronic wounds.

Indexed as

angiogenesis for wound healingcellular responseimmunomodulationinnate immunitypeptide-based biomaterials

Identifiers

PMID38779347
PMCPMC11110865

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.