ArticleInternational journal of cardiology. Heart & vasculature2024
Genetic associations of childhood and adult BMI on chronic heart failure and ischemic stroke: A Mendelian randomization.
Article in International journal of cardiology. Heart & vasculature, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
4 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Mendelian randomization studies on ischemic stroke: a field synopsis and systematic review.Journal of translational medicine · 2025Pooled it
- The causal role of genetically predicted obesity-related traits in heart failure: systematic review and meta-analysis of Mendelian randomization studies.Frontiers in cardiovascular medicine · 2026Review
- Relationship between childhood obesity and cardiovascular and cerebrovascular diseases: a study based on the combination of multiple databases.BMC public health · 2025Article
- Recent highlights from the International Journal of Cardiology Heart & Vasculature: cardiometabolic disease.International journal of cardiology. Heart & vasculature · 2025Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Obesity has been confirmed to be associated with cardiovascular disease, but previous studies have focused on adults, and whether childhood obesity is associated with cardiovascular disease in adulthood needs further research. Objective: This Mendelian randomization (MR) study aimed to investigate the associations of childhood and adult body mass index (BMI) with the risk of chronic heart failure (CHF) and ischemic stroke (IS). Methods: Independent genetic instruments, demonstrating a strong association with exposure at the genome-wide significance level (P < 5 × 10 Results: According to a MR analysis based on a European population, a higher adult BMI was associated with an increased risk of CHF [(odds ratio ( Conclusions: Our study findings provide compelling evidence for the significant influence of adult BMI on the occurrence of CHF and IS. Furthermore, our observations suggest that the positive association between childhood BMI and the risk of CHF in adulthood can largely be attributed to individuals who maintain obesity into later life.
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