Evidence map›Paper›PMID 38779177›Full record

ArticleBioinformatics advances2024

scX: a user-friendly tool for scRNAseq exploration.

Tomás V Waichman, M L Vercesi, Ariel A Berardino, Maximiliano S Beckel, Damiana Giacomini, Natalí B Rasetto, Magalí Herrero, Daniela J Di Bella, Paola Arlotta, Alejandro F Schinder and 1 more

Abstract read
In one paragraph

Article in Bioinformatics advances, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors.

Tomás V WaichmanIntegrative Systems Biology Lab, Leloir Institute, Buenos Aires, CP1405, Argentina.ORCID https://orcid.org/0009-0000-7002-9413
M L VercesiIntegrative Systems Biology Lab, Leloir Institute, Buenos Aires, CP1405, Argentina.
Ariel A BerardinoIntegrative Systems Biology Lab, Leloir Institute, Buenos Aires, CP1405, Argentina.
Maximiliano S BeckelIntegrative Systems Biology Lab, Leloir Institute, Buenos Aires, CP1405, Argentina.
Damiana GiacominiInstituto de Investigaciones Bioquímicas de Buenos Aires, CONICET, Buenos Aires, CP1405, Argentina.
Natalí B RasettoInstituto de Investigaciones Bioquímicas de Buenos Aires, CONICET, Buenos Aires, CP1405, Argentina.
Magalí HerreroInstituto de Investigaciones Bioquímicas de Buenos Aires, CONICET, Buenos Aires, CP1405, Argentina.
Daniela J Di BellaDepartment of Stem Cells and Regenerative Biology, Harvard University, Cambridge, MA 02138, United States.
Paola ArlottaDepartment of Stem Cells and Regenerative Biology, Harvard University, Cambridge, MA 02138, United States.ORCID https://orcid.org/0000-0003-2184-2277
Alejandro F SchinderInstituto de Investigaciones Bioquímicas de Buenos Aires, CONICET, Buenos Aires, CP1405, Argentina.
Ariel ChernomoretzIntegrative Systems Biology Lab, Leloir Institute, Buenos Aires, CP1405, Argentina.ORCID https://orcid.org/0000-0003-2675-353X

Funding

Molecular principles of neuronal maturation and integration in the adult and aging brainR01NS103758 · NINDS · HARVARD UNIVERSITY · PI ARLOTTA, PAOLA, SCHINDER, ALEJANDRO FABIAN · 2018 to 2022
$2.7M
NINDS NIH HHS R01 NS103758
6 · The paper itself

Abstract

Motivation: Single-cell RNA sequencing (scRNAseq) has transformed our ability to explore biological systems. Nevertheless, proficient expertise is essential for handling and interpreting the data. Results: In this article, we present scX, an R package built on the Shiny framework that streamlines the analysis, exploration, and visualization of single-cell experiments. With an interactive graphic interface, implemented as a web application, scX provides easy access to key scRNAseq analyses, including marker identification, gene expression profiling, and differential gene expression analysis. Additionally, scX seamlessly integrates with commonly used single-cell Seurat and SingleCellExperiment R objects, resulting in efficient processing and visualization of varied datasets. Overall, scX serves as a valuable and user-friendly tool for effortless exploration and sharing of single-cell data, simplifying some of the complexities inherent in scRNAseq analysis. Availability and implementation: Source code can be downloaded from https://github.com/chernolabs/scX. A docker image is available from dockerhub as chernolabs/scx.

Identifiers

PMID38779177
PMCPMC11109472

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.