ArticleMayo Clinic proceedings. Innovations, quality & outcomes2024
Phenotypic Clusters and Multimorbidity in Hypermobile Ehlers-Danlos Syndrome.
Article in Mayo Clinic proceedings. Innovations, quality & outcomes, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
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The trial behind it
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Who cites it
22 citing papers in PubMed.
- The WNT/β-catenin Pathway and Matrix Metalloproteinase-9 in hypermobile Ehlers-Danlos Syndrome and Autism Spectrum Disorder: A Possible Connection.Journal of musculoskeletal & neuronal interactions · 2026Review
- Computable Phenotype for Identifying Undiagnosed Hypermobile Ehlers-Danlos Syndrome: Protocol for a Development and Validation Study.JMIR research protocols · 2026Article
- Comorbid Conditions of Ehlers-Danlos Syndromes and Vulvodynia: A Latent Class Analysis.Pain management nursing : official journal of the American Society of Pain Management Nurses · 2026Article
- Health experiences and outcomes of autistic and non-autistic adults with hypermobile Ehlers-Danlos syndrome and hypermobility spectrum disorder.BMC medicine · 2026Article
- Sex differences in self-reported symptoms and comorbidities associated with hypermobile Ehlers-Danlos syndrome and hypermobility spectrum disorders: A retrospective study.Research square · 2026Article
- Ophthalmic Implications of Ehlers-Danlos Syndrome.Clinical ophthalmology (Auckland, N.Z.) · 2026Article
- Exploring cross-category relationships between symptoms in people with hypermobile EDS (hEDS) to identify disability patterns.PloS one · 2026Article
- Detecting comorbidity patterns in rare disease patients with machine learning.Frontiers in epidemiology · 2026Article
- Understanding Comorbidities in Hypermobile Ehlers-Danlos Syndrome: Could a Viral Infection Lead to a Diagnosis?medRxiv : the preprint server for health sciences · 2025Article
- Survival of anterior cruciate ligament reconstruction in patients with Ehlers-Danlos syndrome: A comparison with anatomic risk factors in existing literature.International orthopaedics · 2025Article
- Complex Genetics and Regulatory Drivers of Hypermobile Ehlers-Danlos Syndrome: Insights from Genome-Wide Association Study Meta-analysis.medRxiv : the preprint server for health sciences · 2025Article
- Article
- Proteomic discoveries in hypermobile Ehlers-Danlos syndrome reveal insights into disease pathophysiology.ImmunoHorizons · 2025Article
- Defining the Chronic Complexities of hEDS and HSD: A Global Survey of Diagnostic Challenges, Life-Long Comorbidities, and Unmet Needs.Journal of clinical medicine · 2025Article
- The Financial Impact of Ehlers-Danlos Syndromes on Patients in the United States in 2022.Mayo Clinic proceedings. Innovations, quality & outcomes · 2025Article
- Low vitamin C status and hypermobility-related disorders in patients with bleeding disorder of unknown cause.Haemophilia : the official journal of the World Federation of Hemophilia · 2024Article
- Outcomes of orthopaedic surgery in Ehlers-Danlos syndromes: a scoping review.BMC musculoskeletal disorders · 2024Article
- Variants in the Kallikrein Gene Family and Hypermobile Ehlers-Danlos Syndrome.Research square · 2024Article
- Hypermobile Ehlers-Danlos syndrome and spontaneous CSF leaks: the connective tissue conundrum.Frontiers in neurology · 2024Review
- Co-occurrence of tethered cord syndrome and cervical spine instability in hypermobile Ehlers-Danlos syndrome.Frontiers in neurology · 2024Article
Corrections and comments
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Authors and funding
16 authors.
Funding
Abstract
Objective: To perform a retrospective clinical study in order to investigate phenotypic penetrance within a large registry of patients with hypermobile Ehlers-Danlos syndrome (hEDS) to enhance diagnostic and treatment guidelines by understanding associated comorbidities and improving accuracy in diagnosis. Patients and Methods: From May 1, 2021 to July 31, 2023, 2149 clinically diagnosed patients with hEDS completed a self-reported survey focusing on diagnostic and comorbid conditions prevalence. K-means clustering was applied to analyze survey responses, which were then compared across gender groups to identify variations and gain clinical insights. Results: Analysis of clinical manifestations in this cross-sectional cohort revealed insights into multimorbidity patterns across organ systems, identifying 3 distinct patient groups. Differences among these phenotypic clusters provided insights into diversity within the population with hEDS and indicated that Beighton scores are unreliable for multimorbidity phenotyping. Conclusion: Clinical data on the phenotypic presentation and prevalence of comorbidities in patients with hEDS have historically been limited. This study provides comprehensive data sets on phenotypic presentation and comorbidity prevalence in patients with hEDS, highlighting factors often overlooked in diagnosis. The identification of distinct patient groups emphasizes variations in hEDS manifestations beyond current guidelines and emphasizes the necessity of comprehensive multidisciplinary care for those with hEDS.
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Registered trials
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