Evidence map›Paper›PMID 38778747›Full record

ReviewThe Journal of physiology2025

Molecular and cellular neurocardiology in heart disease.

Beth A Habecker, Donald M Bers, Susan J Birren, Rui Chang, Neil Herring, Matthew W Kay, Dan Li, David Mendelowitz, Marco Mongillo, Johanna M Montgomery and 6 more

Abstract readReview
In one paragraph

Review in The Journal of physiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed.

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  12. Glia of the heart's nervous system.Nature reviews. Neuroscience · 2025
    Review
  13. Review
  14. Article
  15. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Beth A HabeckerDepartment of Chemical Physiology & Biochemistry, Department of Medicine Knight Cardiovascular Institute, Oregon Health and Science University, Portland, OR, USA.ORCID 0000-0002-4658-8730
Donald M BersDepartment of Pharmacology, University of California, Davis School of Medicine, Davis, CA, USA.ORCID 0000-0002-2237-9483
Susan J BirrenDepartment of Biology, Volen Center for Complex Systems, Brandeis University, Waltham, MA, USA.
Rui ChangDepartment of Neuroscience, Department of Cellular and Molecular Physiology, Yale University School of Medicine, New Haven, CT, USA.
Neil HerringBurdon Sanderson Cardiac Science Centre and BHF Centre of Research Excellence, Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, UK.ORCID 0000-0001-8453-6133
Matthew W KayDepartment of Biomedical Engineering, George Washington University, Washington, DC, USA.ORCID 0000-0003-2756-5055
Dan LiBurdon Sanderson Cardiac Science Centre and BHF Centre of Research Excellence, Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, UK.ORCID 0000-0003-2230-9300
David MendelowitzDepartment of Pharmacology and Physiology, George Washington University, Washington, DC, USA.
Marco MongilloDepartment of Biomedical Sciences, University of Padova, Padova, Italy.ORCID 0000-0002-1102-8709
Johanna M MontgomeryDepartment of Physiology and Manaaki Manawa Centre for Heart Research, University of Auckland, Auckland, New Zealand.ORCID 0000-0002-8714-7456
Crystal M RipplingerDepartment of Pharmacology, University of California, Davis School of Medicine, Davis, CA, USA.ORCID 0000-0002-9908-4106
Emmanouil TampakakisDivision of Cardiology, Johns Hopkins School of Medicine, Baltimore, MD, USA.
Annika WinboDepartment of Physiology and Manaaki Manawa Centre for Heart Research, University of Auckland, Auckland, New Zealand.ORCID 0000-0002-9323-3166
Tania ZagliaDepartment of Biomedical Sciences, University of Padova, Padova, Italy.
Nadja ZeltnerDepartments of Biochemistry and Molecular Biology, Cell Biology, and Center for Molecular Medicine, University of Georgia, Athens, GA, USA.ORCID 0000-0001-7892-7154
David J PatersonBurdon Sanderson Cardiac Science Centre and BHF Centre of Research Excellence, Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, UK.ORCID 0000-0002-7399-3256

Funding

Pathophysiological Regulation of Cardiac Myocyte RyR ChannelR01HL092097 · NHLBI · UNIVERSITY OF CALIFORNIA AT DAVIS · PI Donald M Bers, Robyn T Rebbeck · 2010 to 2026
$9.3M
Neurotrophins and post-infarct plasticity in cardiac sympathetic neuronsR01HL093056 · NHLBI · OREGON HEALTH & SCIENCE UNIVERSITY · PI BETH A HABECKER · 2009 to 2026
$7.9M
The Role of Adrenergic Stimulation in ArrhythmogenesisR01HL111600 · NHLBI · UNIVERSITY OF CALIFORNIA-IRVINE · PI Crystal May Ripplinger · 2012 to 2026
$7.1M
CaMKII activation and regulation in adult cardiac myocytesR01HL142282 · NHLBI · UNIVERSITY OF CALIFORNIA AT DAVIS · PI BERS, DONALD M, BOSSUYT, JULIE B · 2018 to 2025
$5.4M
Peripheral Sympathetic Dysfunction in Cardiac DiseaseR01HL146833 · NHLBI · OREGON HEALTH & SCIENCE UNIVERSITY · PI BETH A HABECKER · 2020 to 2026
$5.1M
Precision Medicine for the Peripheral Nervous System Disorder Familiar DysautonomiaR01NS114567 · NINDS · UNIVERSITY OF GEORGIA · PI Nadja Zeltner · 2021 to 2026
$3.0M
Understanding the molecular and functional architecture of diverse body-brain pathwaysR01AT012041 · NCCIH · YALE UNIVERSITY · PI CHANG, RUI · 2022 to 2025
$3.0M
Scalable platform for optimizing human cardiac tissue engineering via optical pacing and on-demand oxygenationR01HL144157 · NHLBI · GEORGE WASHINGTON UNIVERSITY · PI ENTCHEVA, EMILIA, KAY, MATTHEW W. · 2019 to 2022
$2.8M
Hypothalamic neuron activation to blunt myocardial remodeling during chronic sleep apneaR01HL146169 · NHLBI · GEORGE WASHINGTON UNIVERSITY · PI KAY, MATTHEW W. · 2019 to 2022
$2.6M
Novel Mechanisms that Restore Cardiac Parasympathetic Activity Limits Arrhythmias and Cardiac Dysfunction After Myocardial InfarctionR01HL147279 · NHLBI · GEORGE WASHINGTON UNIVERSITY · PI KAY, MATTHEW W., MENDELOWITZ, DAVID · 2020 to 2023
$2.3M
Sex differences in cardiac autonomic remodeling after myocardial infarctionR01HL170626 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Crystal May Ripplinger, Marmar Vaseghi · 2024 to 2026
$2.1M
A molecular and functional dissection of the vagal heart-to-brain physiological circuitsR01HL150449 · NHLBI · YALE UNIVERSITY · PI CHANG, RUI · 2020 to 2023
$1.7M
NCCIH NIH HHS R01 AT012041NHLBI NIH HHS K08 HL145135NHLBI NIH HHS R01 HL092097NHLBI NIH HHS R01 HL093056NHLBI NIH HHS R01 HL111600NHLBI NIH HHS R01 HL142282NHLBI NIH HHS R01 HL144157NHLBI NIH HHS R01 HL146169NHLBI NIH HHS R01 HL146833NHLBI NIH HHS R01 HL147279NHLBI NIH HHS R01 HL150449NHLBI NIH HHS R01 HL170626NINDS NIH HHS R01 NS114567
6 · The paper itself

Abstract

This paper updates and builds on a previous White Paper in this journal that some of us contributed to concerning the molecular and cellular basis of cardiac neurobiology of heart disease. Here we focus on recent findings that underpin cardiac autonomic development, novel intracellular pathways and neuroplasticity. Throughout we highlight unanswered questions and areas of controversy. Whilst some neurochemical pathways are already demonstrating prognostic viability in patients with heart failure, we also discuss the opportunity to better understand sympathetic impairment by using patient specific stem cells that provides pathophysiological contextualization to study 'disease in a dish'. Novel imaging techniques and spatial transcriptomics are also facilitating a road map for target discovery of molecular pathways that may form a therapeutic opportunity to treat cardiac dysautonomia.

Indexed as

Autonomic Nervous SystemHeartHeart DiseasesAnimalsHumansautonomic nervous systemCamKIIcardiac physiologycardiovascular diseaseinduced pluripotent stem cellsneuron‐myocyte co‐culturesoptical mappingoptogenetics

Identifiers

PMID38778747
PMCPMC11582088

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.