Evidence map›Paper›PMID 38778596›Full record

ReviewCurrent stem cell research & therapy2025

The Mechanisms of Mesenchymal Stem Cells in the Treatment of Experimental Autoimmune Encephalomyelitis.

Chunran Xue, Haojun Yu, Ye Sun, Xiying Wang, Xuzhong Pei, Yi Chen, Yangtai Guan

Abstract readReview
PubMed Publisher
In one paragraph

Review in Current stem cell research & therapy, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Chunran XueDepartment of Neurology, Renji Hospital, Shanghai Jiaotong University School of Medicine, 160 Pujian Rd, Shanghai, 200127, P.R. China.
Haojun YuDepartment of Neurology, Renji Hospital, Shanghai Jiaotong University School of Medicine, 160 Pujian Rd, Shanghai, 200127, P.R. China.
Ye SunDepartment of Neurology, Renji Hospital, Shanghai Jiaotong University School of Medicine, 160 Pujian Rd, Shanghai, 200127, P.R. China.
Xiying WangDepartment of Neurology, Renji Hospital, Shanghai Jiaotong University School of Medicine, 160 Pujian Rd, Shanghai, 200127, P.R. China.
Xuzhong PeiSchool of Medicine, Shanghai University, Shanghai, 200444, P.R. China.
Yi ChenDepartment of Neurology, Renji Hospital, Shanghai Jiaotong University School of Medicine, 160 Pujian Rd, Shanghai, 200127, P.R. China.
Yangtai GuanDepartment of Neurology, Renji Hospital, Shanghai Jiaotong University School of Medicine, 160 Pujian Rd, Shanghai, 200127, P.R. China.

Funding

Innovative, Shanghai, 200444, P.R. China, research team of high-level local universities in Shanghai SHSMU-ZDCX20211901National Key R&D Program of China 2020YFA0113100National Natural Science Foundation of China 82071341Science and Technology Innovation Action Plan of the Science and Technology Commission of Shanghai Municipality 20JC1412000
6 · The paper itself

Abstract

Multiple sclerosis (MS) is an inflammatory demyelinating disease of the central nervous system and is a leading cause of disability in young adults. Most therapeutic strategies are based on immunosuppressant effects. However, none of the drugs showed complete remission and may result in serious adverse events such as infection. Mesenchymal stem cells (MSCs) have gained much attention and are considered a potential therapeutic strategy owing to their immunomodulatory effects and neuroprotective functions. Experimental autoimmune encephalomyelitis (EAE), a classical animal model for MS, is widely used to explore the efficacy and mechanism of MSC transplantation. This review summarises the therapeutic mechanism of MSCs in the treatment of EAE, including the effects on immune cells (T cells, B cells, dendritic cells, natural killer cells) and central nervous system-resident cells (astroglia, microglia, oligodendrocytes, neurons) as well as various strategies to improve the efficacy of MSCs in the treatment of EAE. Additionally, we discuss the clinical application of MSCs for MS patients as well as the challenges and prospects of MSC transplantation.

Indexed as

Encephalomyelitis, Autoimmune, ExperimentalMesenchymal Stem CellsMesenchymal Stem Cell TransplantationMultiple SclerosisAnimalsHumansautoimmunityexperimental autoimmune encephalomyelitisimmunomodulationMesenchymal stem cellsmultiple sclerosisneuroprotection.

Identifiers

PMID38778596

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.