Evidence map›Paper›PMID 38778367›Full record

ArticleNeurological research and practice2024

GPi/GPe borderland- a potential sweet spot for deep brain stimulation for chorea in Huntington's disease?

Julia Steinhardt, Simone Zittel, Vera Tadic, Volker Tronnier, Christian Moll, Tobias Bäumer, Alexander Münchau, Dirk Rasche, Norbert Brüggemann

Abstract readLetter
PubMed Full text at PMC Publisher
In one paragraph

Article in Neurological research and practice, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
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1 · What the graph read from it

What it found

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2 · The registry

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3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
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4 · The record

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5 · Who and what money

Authors and funding

9 authors.

Julia SteinhardtDepartment of Neurology and Institute of Neurogenetics, University of Lübeck, Ratzeburger Allee 160, 23538, Lübeck, Germany.
Simone ZittelDepartment of Neurology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Vera TadicDepartment of Neurology and Institute of Neurogenetics, University of Lübeck, Ratzeburger Allee 160, 23538, Lübeck, Germany.
Volker TronnierDepartment of Neurosurgery, University of Lübeck, Lübeck, Germany.
Christian MollDepartment of Neurology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Tobias BäumerCenter of Brain, Behavior, and Metabolism, University of Lübeck, Lübeck, Germany.
Alexander MünchauCenter of Brain, Behavior, and Metabolism, University of Lübeck, Lübeck, Germany.
Dirk RascheDepartment of Neurosurgery, University of Lübeck, Lübeck, Germany.
Norbert BrüggemannDepartment of Neurology and Institute of Neurogenetics, University of Lübeck, Ratzeburger Allee 160, 23538, Lübeck, Germany. norbert.brueggemann@uni-luebeck.de.ORCID http://orcid.org/0000-0001-5969-6899

Funding

Deutsche Forschungsgemeinschaft GRK1957
6 · The paper itself

Abstract

backgroundPallidal deep brain stimulation (GPi-DBS) has been considered as an effective treatment option for medication-refractory Huntington's disease (HD).

objectivesTo identify stimulation-dependent effects on motor symptoms and to determine if these alterations are associated with the local impact of DBS on different pallidal parcellations.

methodsWe prospectively evaluated the effects of bilateral GPi-DBS within one year in 5 HD patients. We evaluated the effects of GPi-DBS on choreatic symptoms and UHDRS. Electrode placement in the pallidum was localized, and the local impact of DBS was estimated.

resultsThe chorea subscore (p < 0.001) and UHDRS total motor score was significantly reduced postoperatively (p = 0.019). Pallidal DBS did not improve other motor symptoms. Activation of the lateral GPi/GPe was associated with improvement in choreatic symptoms (p = 0.048; r = 0.90).

conclusionsOur findings indicate that stimulation of the lateral GPi has a stable effect on choreatic symptoms. The modulation of the electrical field is relevant for motor outcome.

Indexed as

ChoreaDeep brain stimulationGlobus pallidus externusHuntington’s diseaseVolume of tissue activated

Identifiers

PMID38778367
PMCPMC11112842

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