ArticleScientific reports2024
Altered static and dynamic functional network connectivity in primary angle-closure glaucoma patients.
Article in Scientific reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- Cortical gradient compression links cognition and transcriptomic signatures in primary angle-closure glaucoma.Communications biology · 2026Article
- Resting-State fMRI Co-Activation Patterns Reveal Multiscale Brain Functional Alterations in Primary Angle-Closure Glaucoma: Transcriptomic, Cellular, Neurochemical, and Machine-Learning Signatures.Clinical ophthalmology (Auckland, N.Z.) · 2026Article
- Mapping Multiscale Brain Changes in Primary Angle-Closure Glaucoma Using Regional Radiomics Similarity Networks.Clinical ophthalmology (Auckland, N.Z.) · 2026Article
- Altered amplitudes of low-frequency fluctuations in primary open angle glaucoma patients: a resting-state fMRI study.International journal of ophthalmology · 2026Article
- Machine learning with multitype functional connectivity uncovers whole-brain network disruption in primary angle-closure glaucoma.Brain informatics · 2025Article
- Altered intra- and inter-network functional connectivity in pituitary adenomas with chiasmal compression.Quantitative imaging in medicine and surgery · 2025Article
- Hippocampal subregions functional connectivity alterations in primary angle-closure glaucoma patients with cognitive dysfunction: a resting-state fMRI study.BMC neurology · 2025Article
- Cortical functional and structural alterations in rhegmatogenous retinal detachment: a multimodal analysis using surface-based independent component analysis, morphometry, and machine learning.Quantitative imaging in medicine and surgery · 2025Article
- Abnormal topological properties and functional-structural coupling of large-scale brain networks in primary angle-closure glaucoma.Quantitative imaging in medicine and surgery · 2025Article
- A study of dynamic functional connectivity changes in flight trainees based on a triple network model.Scientific reports · 2025Article
- Differences in the amplitude of dynamic low-frequency fluctuations in primary angle-closure glaucoma are associated with gene-molecular multi-omics.Frontiers in medicine · 2025Article
- Aberrant static and dynamic brain functional topological organization in the differentiation of myelin oligodendrocyte glycoprotein antibody-seropositive optic neuritis from seronegative optic neuritis.Frontiers in neuroscience · 2025Article
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Authors and funding
8 authors.
Funding
Abstract
To explore altered patterns of static and dynamic functional brain network connectivity (sFNC and dFNC) in Primary angle-closure glaucoma (PACG) patients. Clinically confirmed 34 PACG patients and 33 age- and gender-matched healthy controls (HCs) underwent evaluation using T1 anatomical and functional MRI on a 3 T scanner. Independent component analysis, sliding window, and the K-means clustering method were employed to investigate the functional network connectivity (FNC) and temporal metrics based on eight resting-state networks. Differences in FNC and temporal metrics were identified and subsequently correlated with clinical variables. For sFNC, compared with HCs, PACG patients showed three decreased interactions, including SMN-AN, SMN-VN and VN-AN pairs. For dFNC, we derived four highly structured states of FC that occurred repeatedly between individual scans and subjects, and the results are highly congruent with sFNC. In addition, PACG patients had a decreased fraction of time in state 3 and negatively correlated with IOP (p < 0.05). PACG patients exhibit abnormalities in both sFNC and dFNC. The high degree of overlap between static and dynamic results suggests the stability of functional connectivity networks in PACG patients, which provide a new perspective to understand the neuropathological mechanisms of optic nerve damage in PACG patients.
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