Evidence map›Paper›PMID 38778146›Full record

ArticleNature neuroscience2024

Simple Behavioral Analysis (SimBA) as a platform for explainable machine learning in behavioral neuroscience.

Nastacia L Goodwin, Jia J Choong, Sophia Hwang, Kayla Pitts, Liana Bloom, Aasiya Islam, Yizhe Y Zhang, Eric R Szelenyi, Xiaoyu Tong, Emily L Newman and 8 more

Abstract read
In one paragraph

Article in Nature neuroscience, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 107 papers.

0numbers the graph read from it
0cells of the map it votes in
107citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

107 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Selective dysregulation of serotonin dynamics in the anterior cingulate cortex and central amygdala following binge alcohol consumption.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026
    Article
  5. Article
  6. ABEL: an active-learning behavior estimation and labeling platform.bioRxiv : the preprint server for biology · 2026
    Article
  7. Article
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  12. Article
  13. Review
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  15. Review
  16. Review
  17. Grooming as a window into the post-stress recuperative process.bioRxiv : the preprint server for biology · 2026
    Article
  18. Automated Profiling of Social Behaviors to Assess the Genetic Basis of Evolution of Aggressive Behaviors in Astyanax mexicanus.Journal of experimental zoology. Part A, Ecological and integrative physiology · 2026
    Article
  19. Article
  20. Article

47 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Nastacia L GoodwinDepartment of Biological Structure, University of Washington, Seattle, WA, USA.ORCID http://orcid.org/0000-0002-1059-7491
Jia J ChoongDepartment of Biological Structure, University of Washington, Seattle, WA, USA.
Sophia HwangDepartment of Biological Structure, University of Washington, Seattle, WA, USA.
Kayla PittsDepartment of Biological Structure, University of Washington, Seattle, WA, USA.ORCID http://orcid.org/0009-0005-5589-6769
Liana BloomDepartment of Biological Structure, University of Washington, Seattle, WA, USA.
Aasiya IslamDepartment of Biological Structure, University of Washington, Seattle, WA, USA.ORCID http://orcid.org/0009-0005-9083-0861
Yizhe Y ZhangDepartment of Biological Structure, University of Washington, Seattle, WA, USA.
Eric R SzelenyiDepartment of Biological Structure, University of Washington, Seattle, WA, USA.ORCID http://orcid.org/0000-0003-2636-0912
Xiaoyu TongNew York University Neuroscience Institute, New York, NY, USA.ORCID http://orcid.org/0000-0003-2113-5943
Emily L NewmanDepartment of Psychiatry, Harvard Medical School McLean Hospital, Belmont, MA, USA.ORCID http://orcid.org/0000-0003-0978-1600
Klaus MiczekDepartment of Psychology, Tufts University, Medford, MA, USA.
Hayden R WrightDepartment of Integrative Physiology and Neuroscience, Washington State University, Pullman, WA, USA.
Ryan J McLaughlinDepartment of Integrative Physiology and Neuroscience, Washington State University, Pullman, WA, USA.
Zane C NorvilleStanford University School of Medicine, Stanford, CA, USA.
Neir EshelDepartment of Psychiatry and Behavioral Sciences, Stanford University, Stanford, CA, USA.ORCID http://orcid.org/0000-0002-5976-2013
Mitra HeshmatiDepartment of Biological Structure, University of Washington, Seattle, WA, USA.ORCID http://orcid.org/0000-0003-1549-558X
Simon R O Nilsson *Department of Biological Structure, University of Washington, Seattle, WA, USA. sronilsson@gmail.com.ORCID http://orcid.org/0000-0001-9591-614X
Sam A Golden *Department of Biological Structure, University of Washington, Seattle, WA, USA. sagolden@uw.edu.ORCID http://orcid.org/0000-0002-2104-2272

Funding

University of Washington Center of Excellence in Opioid Addiction ResearchP30DA048736 · NIDA · UNIVERSITY OF WASHINGTON · PI Charles Chavkin · 2019 to 2026
$13.0M
Nutrition, Obesity and Atherosclerosis Training ProgramT32HL007028 · NHLBI · UNIVERSITY OF WASHINGTON · PI Karin E Bornfeldt · 1985 to 2026
$6.4M
Integrative single-cell spatial transcriptomic, anatomical, and functional profiling of brain-wide ensembles engaged by opioid relapseR01DA059374 · NIDA · UNIVERSITY OF WASHINGTON · PI Sam Golden, Liangcai Gu · 2023 to 2026
$3.1M
Mechanisms of emergence from general anesthesiaR35GM146751 · NIGMS · UNIVERSITY OF WASHINGTON · PI Mitra Heshmati · 2022 to 2026
$2.3M
Neural circuits of frustrationK08MH123791 · NIMH · STANFORD UNIVERSITY · PI ESHEL, NEIR · 2020 to 2024
$1.2M
Connectomics of relapse to aggression seekingR00DA045662 · NIDA · UNIVERSITY OF WASHINGTON · PI GOLDEN, SAM · 2019 to 2021
$736k
Amygdala Circuit Mechanisms for Stress-escalated AggressionK99MH133869 · NIMH · MCLEAN HOSPITAL · PI NEWMAN, EMILY L · 2023 to 2024
$255k
Thalamolimbic circuit mechanisms for social threat processingF32MH125634 · NIMH · MCLEAN HOSPITAL · PI NEWMAN, EMILY L · 2021 to 2023
$193k
Dissociable neural mechanisms of reactive versus appetitive aggressionF31MH125587 · NIMH · UNIVERSITY OF WASHINGTON · PI GOODWIN, NASTACIA · 2021 to 2023
$134k
Alcohol-escalated aggression: A role for medial prefrontal cortical interneurons in miceF31AA025827 · NIAAA · TUFTS UNIVERSITY MEDFORD · PI NEWMAN, EMILY L · 2017 to 2018
$76k
Brain and Behavior Research Foundation (Brain & Behavior Research Foundation) 27082NHLBI NIH HHS T32 HL007028NIAAA NIH HHS F31 AA025827NIDA NIH HHS P30 DA048736NIDA NIH HHS R00 DA045662NIDA NIH HHS R01 DA059374NIGMS NIH HHS R35 GM146751NIMH NIH HHS F31 MH125587NIMH NIH HHS F32 MH125634NIMH NIH HHS K08 MH123791NIMH NIH HHS K99 MH133869U.S. Department of Health & Human Services | National Institutes of Health (NIH) K08MH123791U.S. Department of Health & Human Services | NIH | National Institute of General Medical Sciences (NIGMS) R35GM146751U.S. Department of Health & Human Services | NIH | National Institute of Mental Health (NIMH) 1F31MH125587-01U.S. Department of Health & Human Services | NIH | National Institute of Mental Health (NIMH) F31AA025827U.S. Department of Health & Human Services | NIH | National Institute of Mental Health (NIMH) F32MH125634U.S. Department of Health & Human Services | NIH | National Institute on Drug Abuse (NIDA) 4R00DA045662-02U.S. Department of Health & Human Services | NIH | National Institute on Drug Abuse (NIDA) DA048736U.S. Department of Health & Human Services | NIH | National Institute on Drug Abuse (NIDA) P30DA048736
6 · The paper itself

Abstract

The study of complex behaviors is often challenging when using manual annotation due to the absence of quantifiable behavioral definitions and the subjective nature of behavioral annotation. Integration of supervised machine learning approaches mitigates some of these issues through the inclusion of accessible and explainable model interpretation. To decrease barriers to access, and with an emphasis on accessible model explainability, we developed the open-source Simple Behavioral Analysis (SimBA) platform for behavioral neuroscientists. SimBA introduces several machine learning interpretability tools, including SHapley Additive exPlanation (SHAP) scores, that aid in creating explainable and transparent behavioral classifiers. Here we show how the addition of explainability metrics allows for quantifiable comparisons of aggressive social behavior across research groups and species, reconceptualizing behavior as a sharable reagent and providing an open-source framework. We provide an open-source, graphical user interface (GUI)-driven, well-documented package to facilitate the movement toward improved automation and sharing of behavioral classification tools across laboratories.

Indexed as

Machine LearningNeurosciencesAnimalsHumansSocial Behavior

Identifiers

PMID38778146
PMCPMC11268425

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.